PhD Student in Bioinformatics
Kennziffer: 2024-0300
- Heidelberg
- Full-time
- Clinical Cooperation Unit "Molecular Hematology / Oncology"
„Forschen für ein Leben ohne Krebs“ – das ist unsere Aufgabe am Deutschen Krebsforschungszentrum. Wir erforschen, wie Krebs entsteht, erfassen Krebsrisikofaktoren und suchen nach neuen Strategien, die verhindern, dass Menschen an Krebs erkranken. Wir entwickeln neue Methoden, mit denen Tumore präziser diagnostiziert und Krebspatient:innen erfolgreicher behandelt werden können. Jeder Beitrag zählt – ob in der Forschung, in der Administration oder der Infrastruktur. Das macht unsere tägliche Arbeit so bedeutungsvoll und spannend.
We are seeking for the Clinical Cooperation Unit "Molecular Hematology / Oncology" a
The Clinical Cooperation Unit "Molecular Hematology / Oncology" is a joined department between the German Cancer Research Center (DKFZ) and the Department of Internal Medicine V of the Heidelberg University Hospital with a translational and clinical research focus on Cancer of Unknown Primary (CUP). As a department involved in both research and treatment of CUP, we are committed to scientifically exploring the biology of the disease and linking research findings to patient care.
Our group is currently seeking a PhD student in bioinformatics to work on German Cancer Aid (Deutsche Krebshilfe) funded translational research projects involving tissue of origin prediction and molecular classification based on DNA methylation, DNAseq and RNAseq profiling of tumor samples.
Cancer of Unknown Primary (CUP) is a paradigm metastatic malignancy, in which only metastases but no primary tumor can be identified. To improve on its dismal prognosis, we have recently completed large clinical trials, examining the benefits of targeted treatments and immunotherapy compared to standard chemotherapy. Within the frame of these clinical trials, our translational research program employs multi-omics profiling of large cohorts of primary CUP tumor samples for tissue-of-origin identification, molecular classification and analysis of disease biology.
Ihre Aufgaben:
A PhD position is available in our group for a highly motivated and skilled researcher with a background in bioinformatics or computational biology. The successful candidate will participate in a project aimed at developing computational tools to improve and validate a tissue of origin classifier and a molecular classification framework based on already available DNA methylation, DNAseq and RNAseq data derived from CUP tumor samples generated within clinical trials.
This position offers opportunities to establish novel projects in tumor classification and pathophysiological characterization, as well as expand potential applications beyond tissue-of-origin prediction and molecular classification. The candidate will work with large CUP datasets and in close collaboration with clinical cancer researchers and molecular biologists within a multidisciplinary team.
Ihr Profil:
- Master's degree in bioinformatics, computational biology, genomics, biostatistics, computer science or a related field
- Strong bioinformatics analytical skills and experience with Linux / Unix command line as well as proficiency in programming languages such as R and Python, Bash scripting and deep learning frameworks
- Ability to acquire and process data from sequencing facilities or public resources, run and adapt existing pipelines and develop new ones
- Profound knowledge of cancer biology and cancer genomics is a plus
- Ability to work independently as well as in a team with outstanding self-initiative, positive work attitude, strong work ethic and team spirit
- Excellent communication skills in English as well as writing, presentation and data management skills
Applications must include a CV, cover letter, list of publications, references or recommendation letters and expected availability date.
Unser Angebot:
- Hervorragende Rahmenbedingungen: modernste state-of-the-art Infrastruktur und Möglichkeit zum internationalen Austausch auf Spitzenniveau
- Zugang zu internationalen Forschungs-Netzwerken
- Doktorandengehalt mit den üblichen Sozialleistungen
- 30 Tage Urlaub
- Flexible Arbeitszeiten
- Möglichkeit zur Teilzeitarbeit
- Familienfreundliches Arbeitsumfeld
- Nachhaltig zur Arbeit: Vergünstigtes Deutschland-Jobticket
- Entfalten Sie Ihr volles Potenzial: gezieltes Training und Mentoring durch das DKFZ International PhD Program und den DKFZ Career Service
- Unser betriebliches Gesundheitsmanagement bietet ein ganzheitliches Angebot für Ihr Wohlbefinden
Sie sind interessiert?
Prof. Dr. Alwin Krämer
Telefon: +49 (0)6221/42-1440
