Senior Postdoc for the Division of Personalized Immunotherapies
Kennziffer: 2024-0329
- Mainz
- Vollzeit
- HI-TRON Mainz - Personalized Immunotherapies
„Forschen für ein Leben ohne Krebs“ – das ist unsere Aufgabe am Deutschen Krebsforschungszentrum. Wir erforschen, wie Krebs entsteht, erfassen Krebsrisikofaktoren und suchen nach neuen Strategien, die verhindern, dass Menschen an Krebs erkranken. Wir entwickeln neue Methoden, mit denen Tumore präziser diagnostiziert und Krebspatient:innen erfolgreicher behandelt werden können. Jeder Beitrag zählt – ob in der Forschung, in der Administration oder der Infrastruktur. Das macht unsere tägliche Arbeit so bedeutungsvoll und spannend.
The Helmholtz Institute HI-TRON is a collaboration of the German Cancer Research Center (DKFZ) with the Research Institute for Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz (TRON gGmbH), the University Medical Center Mainz and the Johannes Gutenberg University Mainz. The goal of the partnership is to develop effective immunotherapies and to identify novel biomarkers for assessing the effectiveness of treatment.
To strengthen the HI-TRON team in Mainz, we are seeking a skilled and motivated
The Division of Personalized Immunotherapy (headed by Prof. Dr. Özlem Türeci) at HI-TRON Mainz is looking for a senior postdoc with a strong background in lipid nanoparticle (LNP) formulation and a passion for developing innovative platforms. The successful candidate will be instrumental in advancing fundamental knowledge and creating novel technologies to enable cell-specific biomolecule delivery.
Ihre Aufgaben:
- Lead the development and optimization of LNP formulation for cell-specific biomolecule delivery, including high-throughput screening of lipid compositions and formulation parameters
- Develop and apply methods for LNP purification and characterization
- Apply in vitro and in vivo models to assess biodistribution, efficiency, toxicity, and cell-specific LNP uptake
- Lead the development of LNP targeting strategies using ligand conjugation, peptides, or antibodies for cell/tissue-specific delivery
- Present research findings internally and externally (national and international conferences) and publish in peer-reviewed scientific journals
- Identify new research directions, develop grant proposals, and contribute to securing external funding
Ihr Profil:
- Master's degree and PhD in pharmaceutical sciences, chemistry, bio- or chemical engineering, or related fields
- Extensive experience in LNP formulation methods, including hands-on experience with microfluidic devices, and targeted delivery strategies, including bioconjugation techniques
- Deep knowledge in nanoparticle purification (e.g., size-exclusion chromatography, ultracentrifugation, and dialysis), and characterization (e.g. dynamic light scattering, and Cryo-EM)
- Strong background in relevant in vitro and in vivo models and approaches for evaluating key parameters of nanoparticles, such as efficacy, biodistribution, and toxicity
- Proven publication record in high-impact journals related to biological therapeutics and nanomedicine
- Meticulous, quality-focused, and able to work independently while consistently meeting deadlines with a high degree of accuracy and efficiency
- Strong written and oral communication skills in English with effective interpersonal skills that foster teamwork and collaboration
Unser Angebot:
- Hervorragende Rahmenbedingungen: modernste state-of-the-art Infrastruktur und Möglichkeit zum internationalen Austausch auf Spitzenniveau
- Vergütung nach TV-L inkl. betrieblicher Altersvorsorge und vermögenswirksamer Leistungen
- 30 Tage Urlaub
- Flexible Arbeitszeiten
- Möglichkeit zur Teilzeitarbeit
- Familienfreundliches Arbeitsumfeld
- Nachhaltig zur Arbeit: Vergünstigtes Deutschland-Jobticket
- Unser betriebliches Gesundheitsmanagement bietet ein ganzheitliches Angebot für Ihr Wohlbefinden
- Entfalten Sie Ihr volles Potenzial: Zugang zum DKFZ International Postdoc Program und dem DKFZ Career Service mit gezielten Angeboten für Ihre persönliche Entwicklung fördern Ihre Talente
Sie sind interessiert?
Dr. Ibrahim Murathan Sektioglu
Telefon: +49 (0)6131/179816
