PhD Student in Ferroptosis Research
Kennziffer: 2025-0021
- Heidelberg
- Full-time
- Redox Regulation
„Forschen für ein Leben ohne Krebs“ – das ist unsere Aufgabe am Deutschen Krebsforschungszentrum. Wir erforschen, wie Krebs entsteht, erfassen Krebsrisikofaktoren und suchen nach neuen Strategien, die verhindern, dass Menschen an Krebs erkranken. Wir entwickeln neue Methoden, mit denen Tumore präziser diagnostiziert und Krebspatient:innen erfolgreicher behandelt werden können. Jeder Beitrag zählt – ob in der Forschung, in der Administration oder der Infrastruktur. Das macht unsere tägliche Arbeit so bedeutungsvoll und spannend.
The Division of Redox Regulation is seeking from May 2025 a motivated
The Division of Redox Regulation is an English speaking, international laboratory, offering a highly interactive and collaborative scientific environment. We investigate how normal and tumor cells adapt to oxidative stress. We employ a broad range of techniques, ranging from live-cell imaging with biosensors and genome engineering to proteomics and biochemistry.
Tumor cells often produce more free radicals than healthy cells. In principle, they should be more susceptible to ferroptosis, a form of cell death that is caused by radical-driven lipid oxidation and membrane damage. However, most tumor cells manage to keep radicals under control. Recently, our group discovered a novel radical scavenging system that protects cells against lipid oxidation and membrane damage (Barayeu et al. 2023, Nat Chem Biol 19:28). It is based on so-called persulfides, which are products of sulfur metabolism. In this project, we will investigate the role of persulfides in suppressing ferroptosis-causing radicals. We will try to drive tumor cells into ferroptosis by inhibiting persulfide generation. This project is part of the DFG-funded Priority Program “Ferroptosis: from Molecular Basics to Clinical Applications”.
Ihre Aufgaben:
- Development and application of new tools for studying and controlling radical-induced lipid peroxidation
- Analysis of the role of persulfides in controlling radicals in normal and tumor cells
- Participation in our collaborations with colleagues in the Ferroptosis field
- Contribution to the training and teaching activities of the division
- Preparation of scientific presentations and publications
Ihr Profil:
Applicants must have a master's degree or equivalent in biochemistry, biotechnology, biology or related fields. Candidates should have a very good fundamental understanding of chemistry and at least some prior experience in molecular biology and biochemistry techniques. We expect excellent command of written and oral English with proof of language proficiency (not required for applicants from the EU or North America).
Please submit your application in a single PDF file with a letter of motivation, a statement of research interests, CV, list of publications, transcripts of high school and university certificates, reference letters and contact information for 2-3 referees.
Unser Angebot:
- Hervorragende Rahmenbedingungen: modernste state-of-the-art Infrastruktur und Möglichkeit zum internationalen Austausch auf Spitzenniveau
- Zugang zu internationalen Forschungs-Netzwerken
- Doktorandengehalt mit den üblichen Sozialleistungen
- 30 Tage Urlaub
- Flexible Arbeitszeiten
- Möglichkeit zur Teilzeitarbeit
- Familienfreundliches Arbeitsumfeld
- Nachhaltig zur Arbeit: Vergünstigtes Deutschland-Jobticket
- Entfalten Sie Ihr volles Potenzial: gezieltes Training und Mentoring durch das DKFZ International PhD Program und den DKFZ Career Service
- Unser betriebliches Gesundheitsmanagement bietet ein ganzheitliches Angebot für Ihr Wohlbefinden
Sie sind interessiert?
Prof. Dr. Tobias Dick
Telefon: +49 (0)6221/42-2320
