Postdoctoral Researcher in Cancer Immunity
Kennziffer: 2025-0082
- Mainz
- Vollzeit
- Dermal Oncoimmunology
„Forschen für ein Leben ohne Krebs“ – das ist unsere Aufgabe am Deutschen Krebsforschungszentrum. Wir erforschen, wie Krebs entsteht, erfassen Krebsrisikofaktoren und suchen nach neuen Strategien, die verhindern, dass Menschen an Krebs erkranken. Wir entwickeln neue Methoden, mit denen Tumore präziser diagnostiziert und Krebspatient:innen erfolgreicher behandelt werden können. Jeder Beitrag zählt – ob in der Forschung, in der Administration oder der Infrastruktur. Das macht unsere tägliche Arbeit so bedeutungsvoll und spannend.
The German Cancer Research Center (DKFZ) is the largest biomedical research center in Germany. With more than 3,000 employees, we run an extensive scientific program in the field of cancer research.
In the new Helmholtz Institute for Translational Oncology (HI-TRON) Mainz, the DKFZ cooperates with the Research Institute for Translational Oncology at the University Medical Center of Johannes Gutenberg University Mainz (TRON gGmbH), the Johannes Gutenberg University Mainz (JGU) and the University Medical Center Mainz. The aim of this partnership is to develop pioneering immunotherapies at HI-TRON and to identify new biomarkers for the effectiveness of the treatment.
For the Dermal Oncoimmunology Lab in Mainz we are seeking for as soon as possible a
The Dermal Oncoimmunology Lab (headed by Dr. Hafsa Munir) places fibroblasts at the centre of the immune-regulatory networks in cancer and autoimmunity. We aim to alter the state of fibroblasts in skin cancer towards an autoimmune-like state to induce robust anti-tumour immunity as a novel therapeutic strategy to treat cancer. We are using a combination of single cell proteomic (spectral flow cytometry and immunofluorescence) and genomic (RNA sequencing and spatial transcriptomics) to analyse the state of fibroblast-immune interactions in these disease contexts in primary patient samples and mouse models. We aim to utilise mouse models and complex 3D bioengineered organ-on-chips to analyse the effects of fibroblast manipulation on anti-tumour immunity. Our group is currently looking to recruit an outstanding and highly motivated postdoc to support the development of this research program.
Ihre Aufgaben:
This postdoctoral project will investigate the interactions between fibroblasts and infiltrating immune cells during the initiation and development of cancer and autoimmune diseases of the skin. In co-operation with the group leader, the candidate will be responsible for the day-to-day design, execution and analysis of experimental data. The candidate will further manage collaborations with research groups within and outside of the DKFZ, including clinical partners in Mainz and Heidelberg. Additionally, the successful candidate will present their results at the internal group meetings and at external conferences. Furthermore, the training and supporting of other members of the lab will be an essential part of the role. Long term, successful candidate will contribute to the direction of the research program and contribute to submission of grant applications.
Our lab is a highly interdisciplinary and diverse research environment. We offer the successful candidate a unique opportunity to develop skills in in vitro, in vivo and bioengineered 3D culture systems to model and study these disease processes at high resolution. We aim to recruit a candidate who is open to using multidisciplinary approaches to tackle the research question. As a member of our team you will have a chance to develop your research interests and progress your career as an independent researcher.
Ihr Profil:
Applicants should hold a master's degree and PhD in the field of immunology in cancer or autoimmune disease. Relevant experience in designing, performing and analysing immunological assays, complex cell cultures and/or mouse models is essential. Familiarity with bioinformatic analysis tools is desired but is not required. Excellent organisational and communication skills in English are required for this position.
Unser Angebot:
- Hervorragende Rahmenbedingungen: modernste state-of-the-art Infrastruktur und Möglichkeit zum internationalen Austausch auf Spitzenniveau
- Vergütung nach TV-L inkl. betrieblicher Altersvorsorge und vermögenswirksamer Leistungen
- 30 Tage Urlaub
- Flexible Arbeitszeiten
- Möglichkeit zur Teilzeitarbeit
- Familienfreundliches Arbeitsumfeld
- Nachhaltig zur Arbeit: Vergünstigtes Deutschland-Jobticket
- Unser betriebliches Gesundheitsmanagement bietet ein ganzheitliches Angebot für Ihr Wohlbefinden
- Entfalten Sie Ihr volles Potenzial: Zugang zum DKFZ International Postdoc Program und dem DKFZ Career Service mit gezielten Angeboten für Ihre persönliche Entwicklung fördern Ihre Talente
Sie sind interessiert?
Dr. Hafsa Munir
Telefon: +49 (0)6131 179741
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