Data Scientist
Kennziffer: 2025-0119
- Heidelberg
- Full-time
- Brain Mosaicism and Tumorigenesis
„Forschen für ein Leben ohne Krebs“ – das ist unsere Aufgabe am Deutschen Krebsforschungszentrum. Wir erforschen, wie Krebs entsteht, erfassen Krebsrisikofaktoren und suchen nach neuen Strategien, die verhindern, dass Menschen an Krebs erkranken. Wir entwickeln neue Methoden, mit denen Tumore präziser diagnostiziert und Krebspatient:innen erfolgreicher behandelt werden können. Jeder Beitrag zählt – ob in der Forschung, in der Administration oder der Infrastruktur. Das macht unsere tägliche Arbeit so bedeutungsvoll und spannend.
The Junior Research Group "Brain Mosaicism and Tumorigenesis" is seeking from July 2025 a
The Brain Mosaicism and Tumorigenesis lab investigates how DNA damage and clonal dynamics in neural stem and progenitor cells shape brain development and contribute to pediatric brain tumor initiation. The team is particularly interested in how genomic instability — especially within long neural genes — arises during development and how the brain tolerates or responds to this damage. A central focus is on cellular mosaicism: the genetic variability among brain cells that can influence tissue architecture, neural function, and vulnerability to transformation. By examining how certain clones expand or are eliminated during development, the lab aims to understand the early steps of tumorigenesis in the context of normal brain growth.
To dissect these processes, the lab integrates single-cell sequencing, in vivo lineage tracing in mouse models, organoid systems, and functional genomics approaches. The lab has strong collaboration partner in mathematical modeling complements these experimental methods to quantify clonal competition and predict risk trajectories. Through this multidisciplinary strategy, the lab seeks to reveal how developmental tolerance to DNA damage intersects with mechanisms of early cancer evolution, with the goal of identifying critical windows for intervention and new strategies for early detection or prevention of pediatric brain cancers.
Ihre Aufgaben:
We are looking for a highly motivated data scientist to study genome integrity, cancer evolution, and somatic mosaicism. You will apply and develop multi-omics integrated approaches to investigate genome vulnerability during cell proliferation. The successful candidate should have prior experience in handling genomics, transcriptomics, and single-cell omics datasets. Candidates with sufficient experience in machine learning and deep neural networks are particularly sought. We offer collaboration opportunities to work with world-renowned computational laboratories in data sciences, cancer development, and clonal evolution.
Genomics approaches used in our laboratory include, but are not restricted to, whole genome sequencing, targeted sequencing, Hi-C, 3C- or 4C-based sequencing, nascent and mature RNA-seq, ChIP-seq, ATAC-seq, Repli-Seq, Okazaki fragment sequencing, and single-cell transcriptomic and spatial omics.
Please submit your curriculum vitae, master's and/or doctoral degree certificates, and a letter of motivation via the DKFZ application portal. Applications sent through email cannot be considered.
Ihr Profil:
- M.Sc. or Ph.D. degree in bioinformatics or a related scientific discipline (e.g. statistics, computer science, physics or molecular biotechnology)
- Prior bioinformatics training in transcriptomics, epigenomics, and genomics; deep neural network and machine learning experiences are preferred
- Strong analytical skills, as well as broad experience with scripting languages (e.g. Python, R, Bash); knowledge of common bioinformatics software and access to databases are essential
- Basic understanding of biology
- Proficient in English
- German is not required
- Collaborative, communicative, ambitious, attention to detail, curiosity-driven, and organized, the ability to work in a multidisciplinary international team will be expected
- Professional time management
Unser Angebot:
- Hervorragende Rahmenbedingungen: modernste state-of-the-art Infrastruktur und Möglichkeit zum internationalen Austausch auf Spitzenniveau
- 30 Tage Urlaub
- Flexible Arbeitszeiten
- Vergütung nach TV-L inkl. betrieblicher Altersvorsorge und vermögenswirksamer Leistungen
- Möglichkeit zur mobilen Arbeit und Teilzeitarbeit
- Familienfreundliches Arbeitsumfeld
- Nachhaltig zur Arbeit: Vergünstigtes Deutschland-Jobticket
- Entfalten Sie Ihr volles Potenzial: gezielte Angebote für Ihre persönliche Entwicklung fördern Ihre Talente
- Unser betriebliches Gesundheitsmanagement bietet ein ganzheitliches Angebot für Ihr Wohlbefinden
Sie sind interessiert?
Dr. Pei-Chi Wei
Telefon: +49 6221/42-3251
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