Bioinformatics Data Engineer
Kennziffer: 2025-0175
- Heidelberg
- Full-time
- Junior Research Group "Developmental Origins of Pediatric Cancer"
„Forschen für ein Leben ohne Krebs“ – das ist unsere Aufgabe am Deutschen Krebsforschungszentrum. Wir erforschen, wie Krebs entsteht, erfassen Krebsrisikofaktoren und suchen nach neuen Strategien, die verhindern, dass Menschen an Krebs erkranken. Wir entwickeln neue Methoden, mit denen Tumore präziser diagnostiziert und Krebspatient:innen erfolgreicher behandelt werden können. Jeder Beitrag zählt – ob in der Forschung, in der Administration oder der Infrastruktur. Das macht unsere tägliche Arbeit so bedeutungsvoll und spannend.
The Junior Research Group "Developmental Origins of Pediatric Cancer" is seeking from September 2025 a
Our lab studies how neurodevelopmental principles underlie pediatric cancer formation. We investigate the underlying genetic programs of normal development to dissect how differentiation goes wrong during tumorigenesis. We also investigate tumor-specific mechanisms of transformation and growth.
To understand these processes, the lab integrates single-cell sequencing, whole-genome sequencing, RNA sequencing, mouse models, iPSC-derived organoids, and functional genomics approaches. The lab has strong collaboration partner in computational biology and bioinformatics, and the candidate will be jointly supervised by the “Clinical Bioinformatics - Translational Genomics” group (Division of Pediatric Neurooncology). Through this multidisciplinary approach, the lab seeks to reveal how hijacking of developmental trajectories leads to pediatric brain cancers.
Ihre Aufgaben:
We are looking for a data engineer
- to generate and harmonize user-friendly, standardized data analysis pipelines for a variety of computational tasks, including, but not limited to, mutation calling, bulk and single-cell RNA-seq analysis, and ChIP-seq/Cut&Run datasets
- to perform large-scale data integration of single-cell RNA-seq datasets and generate user-friendly applications for data exploration
- to perform data analysis derived from diverse scientific topics in collaboration with PhD students and postdocs
- to train students and postdocs in basic data analysis pipeline implementation
- to explore pipelines for analyzing high-content image analysis.
Genomics approaches used in our laboratory include, but are not limited to, whole-genome sequencing, RNA-seq, ChIP-seq, Cut&Run, single-cell transcriptomics, and spatial omics. Imaging approaches include multiplexing confocal imaging and live-cell imaging.
Ihr Profil:
- M.Sc. or Ph.D. in bioinformatics, computational biology, statistics, computer science, physics, molecular biotechnology, or a related discipline; prior bioinformatics training in transcriptomics, epigenomics, and/or genomics is required
- Strong analytical skills as well as broad experience with scripting languages (e.g. Python, R, Bash); knowledge of common bioinformatics software and access to databases are essential
- Experience in analysis of large-scale imaging analysis preferred, but not required
- Basic understanding of biology
- Proficient in English, German is not required
- Collaborative, communicative, ambitious, attention to detail, curiosity-driven, and organized, the ability to work in a multidisciplinary international team will be expected
- Professional time management
Please submit your curriculum vitae, master's and/or doctoral degree certificates, a letter of motivation, and contact information of 2 references, via the DKFZ application portal. Applications sent through email cannot be considered.
Unser Angebot:
- Hervorragende Rahmenbedingungen: modernste state-of-the-art Infrastruktur und Möglichkeit zum internationalen Austausch auf Spitzenniveau
- 30 Tage Urlaub
- Flexible Arbeitszeiten
- Vergütung nach TV-L inkl. betrieblicher Altersvorsorge und vermögenswirksamer Leistungen
- Möglichkeit zur Teilzeitarbeit
- Familienfreundliches Arbeitsumfeld
- Nachhaltig zur Arbeit: Vergünstigtes Deutschland-Jobticket
- Entfalten Sie Ihr volles Potenzial: gezielte Angebote für Ihre persönliche Entwicklung fördern Ihre Talente
- Unser betriebliches Gesundheitsmanagement bietet ein ganzheitliches Angebot für Ihr Wohlbefinden
Sie sind interessiert?
Dr. Lena Kutscher
Telefon: +49 6221/42-4622
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