PhD Student in Non-Coding Cancer Biology
Kennziffer: 2025-0202
- München
- Full-time
- DKTK partner site Munich - Institute of Pathology, LMU Munich
„Forschen für ein Leben ohne Krebs“ – das ist unsere Aufgabe am Deutschen Krebsforschungszentrum. Wir erforschen, wie Krebs entsteht, erfassen Krebsrisikofaktoren und suchen nach neuen Strategien, die verhindern, dass Menschen an Krebs erkranken. Wir entwickeln neue Methoden, mit denen Tumore präziser diagnostiziert und Krebspatient:innen erfolgreicher behandelt werden können. Jeder Beitrag zählt – ob in der Forschung, in der Administration oder der Infrastruktur. Das macht unsere tägliche Arbeit so bedeutungsvoll und spannend.
Together with university partners at seven renowned partner sites, we have established the German Cancer Consortium (DKTK).
For the DKTK partner site Munich, we are seeking for the next possible date a
We are looking for a PhD student in the field of molecular cancer biology to join our new Junior Research Group “Non-Coding Cancer Biology” within the Institute of Pathology.
Our lab investigates the role of the non-coding genome in cancer. We use genome-wide CRISPRi screens to identify oncogenic super-enhancers that are essential to cancer cell survival with the goal of identifying new therapeutic targets. Using novel Cas13d-based screening methods and antisense oligo technology, we then pinpoint specific non-coding transcripts within these essential super-enhancers for therapeutic exploitation. This strategy lays the groundwork for first-of-its-kind precision epigenetic therapies and introduces a paradigm-shifting framework for exploiting the non-coding genome in oncology.
Ihre Aufgaben:
As a PhD student in our research team you will have the unique opportunity to:
- Gain expertise in the exciting and novel area of non-coding regulatory genomics and epigenomics
- Learn and employ cutting-edge CRISPR methods including epigenome editing, CRISPR-based live-cell imaging, and RNA-targeting CRISPR
- Perform next-generation CRISPR screens including CRISPRi, CRISPRa, and RNA-targeting CRISPR systems (Cas13d)
- Employ bioinformatics platforms and computational pipelines for the analysis of CRISPR screening, RNA sequencing, DNA sequencing, and ChIP-seq datasets
- Experience research at the interface between experimental and computational biology
- Interact within a diverse and multidisciplinary environment of biologists, clinicians, pathologists, and computational scientists within the DKTK network and the LMU Munich
Ihr Profil:
We are looking for a talented and enthusiastic doctoral candidate who is highly motivated to make a meaningful contribution to cancer research. Previous exposure to and experience with basic molecular biology techniques, cell culture, CRISPR, and bioinformatics as well as a profound interest in cancer and genome biology are essential.
You should hold a diploma or master’s degree in biochemistry, biology, molecular/translational medicine, or related subjects. Due to the interdisciplinary framework and close collaboration between wet-lab and computational scientists, good communicative skills as well as fluency in English are essential. Good written and spoken German skills are also required.
Unser Angebot:
- Hervorragende Rahmenbedingungen: modernste state-of-the-art Infrastruktur und Möglichkeit zum internationalen Austausch auf Spitzenniveau
- Zugang zu internationalen Forschungs-Netzwerken
- Doktorandengehalt mit den üblichen Sozialleistungen
- 30 Tage Urlaub
- Flexible Arbeitszeiten
- Möglichkeit zur Teilzeitarbeit
- Familienfreundliches Arbeitsumfeld
- Nachhaltig zur Arbeit: Vergünstigtes Deutschland-Jobticket
- Entfalten Sie Ihr volles Potenzial: gezieltes Training und Mentoring durch das DKFZ International PhD Program und den DKFZ Career Service
- Unser betriebliches Gesundheitsmanagement bietet ein ganzheitliches Angebot für Ihr Wohlbefinden
Sie sind interessiert?
Christine Koppenhöhl
Telefon: +49 (0)89/4400-54627
Bewerbungen per E-Mail können leider nicht angenommen werden.
Bitte beachten Sie auch, dass wir per Post eingereichte Bewerbungen nicht zurückschicken können.
