Postdoctoral Researcher in Inter-organ Communication between Liver and Heart
Kennziffer: 2025-0307
- Heidelberg
- Full-time
- Systems Biology of Signal Transduction
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The Division "Systems Biology of Signal Transduction", headed by Prof. Dr. Ursula Klingmüller, is seeking a
Our division integrates advanced experimental methods with mechanistic mathematical modeling to decipher how cells respond to environmental signals in health and disease. Understanding the fine-tuned regulation of signal transduction pathways is essential to uncover disease mechanisms, to identify novel therapeutic targets, particularly in cancer and chronic liver disease, and to predict innovative intervention strategies.
As part of the EU-funded ARTEMIS network, we contribute to the development of digital twin solutions as clinical decision support systems and investigate the liver-heart communication. A particular focus is on the risk stratification of cardiovascular disease (CVD) in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) at various stages. In our interdisciplinary effort, we combine mass spectrometry-based proteomics with dynamic pathway modeling to identify relevant biomarkers to diagnose patients with high risk for adverse cardiovascular events or outcomes, which might help to optimize their clinical care.
To support our interdisciplinary team, we are looking for a postdoctoral researcher to start in February 2026 develop virtual twins for inter-organ communication between the liver and heart.
Ihre Aufgaben:
- Development of a mass spectrometry-based method for the quantitative analysis of liver and heart tissue and plasma proteins from MASLD patients and mouse models, including the implementation of experimental strategies, project planning, literature research on MASLD/CVD, data analysis pipelines, and mass spectrometry
- Conducting experiments to identify proteins relevant for the cross-talk between the liver and heart with relevance in MASLD patients
- Documentation and publication of research findings in scientific journals and book chapters, as well as presentation of results at lectures and scientific conferences
- Coordination and review of legal and scientific documents (e.g., Joint Consortia Agreements, Data Sharing Agreements, etc.)
- Development of medical products (medical devices) and securing of inventions through intellectual property rights (e.g., patents), and contribution to the patent and commercialization strategy for the project
Ihr Profil:
- PhD in biochemistry, systems biology, bioinformatics, or a related life science discipline
- Proven expertise in mass spectrometry-based proteomics and knowledge in liver and/or cardiovascular diseases
- Solid experience in handling complex omics datasets and in applying statistical and computational tools for data analysis
- Familiarity with mathematical modeling in systems biology and pathway-level data integration is advantageous
- Excellent teamwork and communication skills with proficiency in English, with a motivation to work in a collaborative, interdisciplinary environment
- A strong scientific track record demonstrated by publications in peer-reviewed journals
Unser Angebot:
- Hervorragende Rahmenbedingungen: modernste state-of-the-art Infrastruktur und Möglichkeit zum internationalen Austausch auf Spitzenniveau
- Vergütung nach TV-L inkl. betrieblicher Altersvorsorge und vermögenswirksamer Leistungen
- 30 Tage Urlaub
- Flexible Arbeitszeiten
- Möglichkeit zur Teilzeitarbeit
- Familienfreundliches Arbeitsumfeld
- Nachhaltig zur Arbeit: Vergünstigtes Deutschland-Jobticket
- Unser betriebliches Gesundheitsmanagement bietet ein ganzheitliches Angebot für Ihr Wohlbefinden
- Entfalten Sie Ihr volles Potenzial: Zugang zum DKFZ International Postdoc Program und dem DKFZ Career Service mit gezielten Angeboten für Ihre persönliche Entwicklung fördern Ihre Talente
Sie sind interessiert?
Prof. Dr. Ursula Klingmüller
Telefon: +49 (0)6221/42-4481
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