Postdoc – Spatial Single-Cell Perturbation Maps
Kennziffer: 2026-0031
- Heidelberg
- Full-time
- Signaling and Functional Genomics
The German Cancer Research Center (DKFZ) is one of Europe’s largest cancer research centers. “Research for a life without cancer" is the mission of our world-class scientists and all our team members.
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The Division of Signaling and Functional Genomics, headed by Prof. Dr. Michael Boutros at the German Cancer Research Center in Heidelberg, is seeking for the next possible date a
Our division is interested in systematically analyzing developmental-oncogenic signaling pathways using a combination of experimental and computational approaches. Within this project, we are creating perturbation-based genetic maps at the level of individual cells by using spatial single-cell sequencing technologies.
The position is funded by the ERC Synergy Project DECODE as a close collaboration between DKFZ, EMBL and Heidelberg University.
Ihre Aufgaben:
As part of our team, we are seeking a highly motivated postdoctoral fellow to lead the performance of novel spatial and single-cell profiling in combination with genome-editing approaches in high-throughput. The ERC DECODE project develops and applies leading-edge system genetics methods to decode context-dependent genetic networks in vivo. To achieve this, the ERC Synergy Project brings together experimental and theoretical groups with complementary expertise in model organism genetics and cellular phenotyping, single-cell genomics, statistics, and computational biology. Building on our combined expertise, we are creating functional genetic maps using conditional CRISPR/Cas9-based single and higher-order knockout perturbations combined with single-cell expression profiling and imaging. We expect that this project will advance new genome-editing and single-cell approaches and will provide fundamental insights into the cellular circuitries that govern processes in a metazoan organism. The particular focus of the postdoctoral position will be on the development, automation and application of single-cell methodologies for genome-editing analyses.
Ihr Profil:
We are looking for a highly motivated postdoctoral researcher, preferably with a strong background in the development of single-cell technologies, CRISPR, high-throughput technologies, and molecular biology. Candidates should have an advanced academic degree (master's and Ph.D.) in biology, biochemistry, biotechnology or a related field and have published previously in peer-reviewed journals. Knowledge in single-cell RNA-seq, laboratory automation and data analysis, and/or Drosophila genetics is an advantage. The candidate should be able to work independently and also have excellent teamwork skills. The position further requires organizational qualifications and the ability to communicate effectively with internal and external collaborators. An excellent written and oral command of English is essential.
The application shall include a CV, a letter of motivation, degree certificates, and names and contact information of at least two references.
Unser Angebot:
- Hervorragende Rahmenbedingungen: modernste state-of-the-art Infrastruktur und Möglichkeit zum internationalen Austausch auf Spitzenniveau
- Vergütung nach TV-L inkl. betrieblicher Altersvorsorge und vermögenswirksamer Leistungen
- 30 Tage Urlaub
- Flexible Arbeitszeiten
- Möglichkeit zur Teilzeitarbeit
- Familienfreundliches Arbeitsumfeld
- Nachhaltig zur Arbeit: Vergünstigtes Deutschland-Jobticket
- Unser betriebliches Gesundheitsmanagement bietet ein ganzheitliches Angebot für Ihr Wohlbefinden
- Entfalten Sie Ihr volles Potenzial: Zugang zum DKFZ International Postdoc Program und dem DKFZ Career Service mit gezielten Angeboten für Ihre persönliche Entwicklung fördern Ihre Talente
Sie sind interessiert?
Dr. Ulrike Hardeland
Telefon: +49(0)6221/42-1961
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