Position: Postdoc in Bioinformatics

Department: Signaling and Functional Genomics

Code number: 2022-0160

The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.

Job description:

A postdoctoral position for a computational biologist / bioinformatician is available in the group of Prof. Dr. Michael Boutros (Division of Signaling and Functional Genomics) at the German Cancer Research Center as part of a project to develop integrative methods and resources for high-throughput screening and sequencing. In our research group, we systematically analyze oncogenic pathways using a combination of genomic and functional genomic approaches. We develop and apply computational methods for functional screens in cells and organoids that require cutting-edge bioinformatics approaches for experimental design, data analysis and integration of genomic data sets. Previously, we have developed several software tools for the design of large-scale functional genomic experiments (E-CRISP for the design of CRISPR/Cas experiments; Heigwer et al, Nature Methods 2014) and integrative databases (GenomeCRISPR, GenomeRNAi). The position will contribute to a project to further extend functional screening approaches to patient-derived cancer organoids.

Your tasks will include the following:

  • Development and extension of internal and external databases for high-throughput screening experiments
  • Conception of analysis workflows
  • Analysis and visualization of results
  • Collaboration with internal and international partners
  • Development and support of web services

 

Requirements:

  • Academic degree (Master and Ph.D.) with a background in computer science, bioinformatics, molecular biology, physics or related field
  • Experience in object-oriented software development and building web-based applications
  • Very good knowledge of at least one scripting language (e.g. Perl, Python) and with Bash scripting
  • Good knowledge in relational and document-oriented database design (e.g. MySQL, MongoDB)
  • Good knowledge in the development of modern web applications (e.g. Express.js, AngularJS)
  • Knowledge of Bioconductor/R and Docker containers is of advantage
  • Good analytical and (bio)statistical skills
  • Basic understanding of procedures in high-throughput screening and sequencing
  • Experience with Linux systems
  • Ability to work as part of an interdisciplinary team
  • Excellent communication, organizational and interpersonal skills
  • An excellent written and oral command of English is essential

The application shall include a CV, a letter of motivation, degree certificates and names and contact information of at least two references.

We offer:

  • Interesting, versatile workplace
  • International, attractive working environment
  • Campus with modern state-of-the-art infrastructure
  • Salary according to TV-L including social benefits
  • Possibility to work part-time
  • Flexible working hours
  • Comprehensive further training program
  • Access to the DKFZ  International Postdoc Program

Important notice:

The DKFZ is subject to the regulations of the Infection Protection Act (IfSG). As a consequence, only persons who present proof of immunity against measles as well as against COVID-19 may work at the DKFZ.

Earliest possible start date: as soon as possible

Duration: The position is initially limited to 2 years with the possibility of prolongation. ‚Äč

The position can in principle be part-time.

Application deadline: 31.05.2022

Contact:

Prof. Dr. Michael Boutros
Phone +49 (0)6221/42-1950

Please note that we do not accept applications submitted via email.

The DKFZ is committed to increase the proportion of women in all areas and positions in which women are underrepresented. Qualified female applicants are therefore particularly encouraged to apply.

Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.

To apply for a position please use our online application portal (https://www.dkfz.de/en/stellenangebote/index.php).

We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebsforschungszentrum, Personalabteilung, Im Neuenheimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apologize for any inconvenience this may cause.