Position: Postdoc in Wnt Signaling
Department: Signaling and Functional Genomics
Code number: 2022-0173
The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.
The research group "Signaling and Functional Genomics", headed by Prof. Dr. Michael Boutros at the German Cancer Research Center in Heidelberg, is interested in key signaling pathways and their role in development and cancer. A particular focus lies on the Wnt pathway that plays essential roles during stem cell maintenance and human diseases like colorectal cancer.
We are seeking a highly motivated postdoctoral fellow to join an EIC transition project team. In this project we are developing and validating a new drug discovery platform based on patient-derived organoids (PDOs) and machine learning-assisted phenotypic target validation. The project will target critical, cell-specific vulnerabilities in cancer and is based on technologies and approaches developed previously during an ERC project in our group. Initially, this platform will be used to identify therapeutics to target stem cell signaling pathways in colorectal cancer. As recent evidence indicated a tight link of stem cell plasticity and changes in Wnt levels, one of your main tasks will be to develop and set up novel drug discovery approaches to identify interfering agents for Wnt secretion and signaling that can modulate this plasticity. As part of the project, you will develop an organoid-based reporter for Wnt secretion and signaling which can be used for drug screening and identification of antagonists and agonists. PDO and complex phenotypic drug screens will provide a unique opportunity for drug discovery and development of agents for therapeutic use in cancer.
We are looking for a highly motivated postdoctoral researcher, preferably with a strong background in molecular biology, cellular biology and protein biochemistry. Experience in high-throughput technologies, data analysis, and organoids are of advantage. Candidates should have an advanced academic degree (Master's and Ph.D.) in biology, biochemistry, biotechnology or a related field and have published previously in peer-reviewed journals. You should be able to work independently and also have excellent team working skills. The position further requires organizational qualifications and the ability to communicate effectively with internal and external collaborators. An excellent written and oral command of English is essential.
The application shall include a CV, a letter of motivation, degree certificates and names and contact information of at least two references.
- Interesting, versatile workplace
- International, attractive working environment
- Campus with modern state-of-the-art infrastructure
- Salary according to TV-L including social benefits
- Possibility to work part-time
- Flexible working hours
- Comprehensive further training program
- Access to the DKFZ International Postdoc Program
The DKFZ is subject to the regulations of the Infection Protection Act (IfSG). As a consequence, only persons who present proof of immunity against measles as well as against COVID-19 may work at the DKFZ.
Earliest possible start date: as soon as possible
Duration: The position is initially limited to 2 years with the possibility of prolongation.
The position can in principle be part-time.
Application deadline: 30.06.2022
Prof. Dr. Michael Boutros
Phone +49 (0)6221/42-1950
Please note that we do not accept applications submitted via email.