Position: Team Leader Genomics Data Infrastructure
Department: Computational Genomics & Systems Genetics
Code number: 2022-0275
The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.
As part of the National Genome Medicine Initiative genomDE, the German Ministry of Health has recently launched a pilot project to establish the technical, legal and scientific concept for the future of genome medicine in Germany. In the context of this initiative, DKFZ, together with leading biomedical partners across Germany, seeks to develop technical solutions for genomDE and implement infrastructure elements as technology pilots. genomDE aims to establish a framework for the inclusion and medical interpretation of quality-controlled genome sequencing data in routine diagnostics, to advance treatment options in cancer and rare genetic diseases. It is also envisioned that the data generated will be made available for research in a secure cloud environment, thereby enabling secondary use while ensuring highest standards of data protection for the sensitive genomic data. The technical development of these solutions will be closely connected to and coordinated with the ongoing development of the German Human Genome-Phenome Archive (GHGA), a national research infrastructure for genome data (NFDI) coordinated at DKFZ. In addition, it will be involved in the Pan-European “Beyond 1 Million Genomes” (B1MG) initiative which recently was selected for funding to build up a European “Genomics Data Infrastructure (GDI)".
At the national level, the activities are embedded in leading clinical networks such as e.g. the National Center for Tumor Diseases (NCT), the Centers for Personalized Medicine (ZPM) as well as the Medical Informatics Initiative. The project will also be closely connected to and interact with other international initiatives and networks such as, the European Genome-Phenome Archive (EGA) and the Global Alliance for Genomics and Health (GA4GH). The position will be situated between the GHGA main office at DKFZ and the research group of Prof. Oliver Stegle (Division of Computational Genomics and Systems Genetics) and it will involve close interactions with Prof. Stefan Fröhling and his team at the NCT.
For the development of the genomDE and B1MG / GDI data infrastructure architecture, as well as for ensuring connectivity with GHGA and other international initiatives, we are looking to appoint an experienced computer scientist or bioinformatician. Suitable candidates will have the opportunity to build an interdisciplinary team to foster the conceptual and technical alignment between GHGA and other technical infrastructures and parties involved in genomDE and B1MG. The coordinator will take responsibility for the development of novel technical concepts and coordinate the software development with special emphasis on the IT security aspects to be covered.
- Development and shaping of technical concepts for innovative data infrastructures relevant for biomedical research and healthcare
- Coordination of the interaction of technical working groups within genomDE, B1MG and GHGA
- Coordination and adjustment of technical concepts between all involved parties
- Coordination of the development of pilots for the connection between B1MG / GDI, genomDE and the GHGA core software architecture
- Contribute to the development (back-end / front-end) of pilot software
- Contribute to the development of IT security concepts for GHGA and genomDE for the secure operations of IT infrastructures for genomics data
- Participation in international development networks of the federated EGA architecture and the upcoming B1MG / Genome Data Infrastructure (GDI) projects
- Collaboration with local and international developers
We offer you a senior position at the interface between leading initiatives in biomedical data science with a significant degree of independence and a strong perspective for a successful future career path.
- Be involved in the shaping of innovative, cross-border, IT infrastructures enabling innovative personal medicine approaches in Germany
- Get exposed to a plethora of fields ranging from AI-guided clinical decision making to modern web development technologies
- Work with an interdisciplinary team of experts bringing state-of-the-art biomedical research closer to clinics and patients
- Directly contribute to national and international organizations such as genomDE, Beyond 1 Million Genomes, the Global Alliance for Genomics and Health (GA4GH), the European Genome-Phenome Archive (EGA) and ELIXIR shaping future of genomics across borders
- Widen your expertise with extensive possibilities of training programs, seminars and conferences
- PhD in computer science, medical informatics, bioinformatics, computational biology or similar background with a focus on bioinformatics or data science
- Alternatively, an MSc or equivalent qualification with complementary years of relevant experience in IT environments
- Previous experience in a similar role including the operation of data infrastructures in an academic or industrial setting, ideally in a cloud environment
- Extensive experience in IT and bioinformatics with relevant experience in the development, coordination and operation of data infrastructures, software development or cloud computing
- Excellent project management skills proven in an academic or industrial setting are a prerequisite
- Experience in health research data management, including genomics data
- Experience in the communication with domain experts around health research data management, acquisition and sharing
The ideal applicant should have demonstrated the ability to work independently and creatively. The candidate should have excellent communications skills in English and be able to articulate the technical needs precisely, set clear goals and work within an interdisciplinary setting, while communicating with other external partners.
- Interesting, versatile workplace
- International, attractive working environment
- Campus with modern state-of-the-art infrastructure
- Salary according to TV-L including social benefits
- Possibility to work part-time
- Flexible working hours
- Comprehensive further training program
The DKFZ is subject to the regulations of the Infection Protection Act (IfSG). As a consequence, only persons who present proof of immunity against measles as well as against COVID-19 may work at the DKFZ.
Earliest Possible Start Date: as soon as possible
Duration: The position is initially limited to 2 years with the possibility of prolongation.
The position can in principle be part-time.
Application Deadline: 23.08.2022
Prof. Dr. Oliver Stegle
Phone +49 (0)6221/42-3598
Please note that we do not accept applications submitted via email.