Job description:

Our research division explores the molecular mechanisms underlying carcinogenesis with a special emphasis on non-canonical and novel types of mutations in cancer (EMBO Mol Med 2016, Nat Commun 2019, Nat Cell Biol 2020). The method spectrum in our lab ranges from innovative techniques from molecular and cell biology like diverse CRISPR techniques (Nucleic Acids Res 2017, Hepatology 2018) or RNA-protein complex identification (Nature 2015, Mol Cell 2019, Nat Protoc 2020) to applications in bioinformatics and biochemistry. Our lab in Freiburg is newly equipped with state-of-the-art instrumentation.

We are seeking a highly motivated, ambitious graduate student (PhD student) with strong interest in cancer genetics and ideally experience in the area of molecular biology and / or cancer research. The core project of the graduate student will be the functional characterization and analysis of genetic alterations in cancer in high throughput. Research questions will include the mutational impact at the cellular and molecular level and their mechanistic consequences. An innovative screen using CRISPR site-directed mutagenesis shall unravel their impact on human cells. Comprehensive resources as well as established protocols to build on are available.

Requirements:

You are a highly motivated graduate (PhD) student with a very good MSc degree in molecular biology, biochemistry or a related topic and are eager to pursue research projects in tumor genetics and the molecular biology of cancer including high throughput approaches and genome editing with ambition, creativity, independence and team spirit. You work efficiently, goal-oriented and accurate, have a deep interest in research and are proficient in English.