Position: Postdoctoral Position – Single-Cell Technologies
Department: Signaling and Functional Genomics
Code number: 2022-0335
The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.
The research group "Signaling and Functional Genomics", headed by Prof. Dr. Michael Boutros at the German Cancer Research Center (DKFZ) in Heidelberg, is systematically analyzing developmental-oncogenic signaling pathways using both experimental and computational approaches. Within this ERC project, we will create perturbation-based genetic maps at the level of individual cells by using tissue-specific CRISPR knock-out and single-cell sequencing technologies. The position is funded by the ERC Synergy Project DECODE as a close collaboration between DKFZ, EMBL and Heidelberg University.
As part of our team, we are seeking a highly motivated postdoctoral fellow to lead the development and application of novel single-cell perturbation methodologies. The ERC DECODE project develops and applies leading-edge system genetics methods to decode context-dependent genetic networks in vivo. To achieve this, the ERC Synergy Project brings together experimental and theoretical groups with complementary expertise in model organism genetics and cellular phenotyping, single-cell genomics, statistics and computational biology. Building on our combined expertise, we will create functional genetic maps using conditional CRISPR/Cas-based single and higher order knockout perturbations combined with single-cell expression profiling and imaging. We expect that this project will advance new experimental approaches and will provide fundamental insights into the cellular circuitries that govern many processes in a metazoan organism. The particular focus of the postdoctoral position will be on the development, automation and application of single-cell methodologies for perturbation-based analyses.
We are looking for a highly motivated postdoctoral researcher, preferably with a strong background in the development of single-cell technologies, CRISPR, high-throughput technologies and molecular biology. Candidates should have an advanced academic degree (Ph.D.) in biology, biochemistry, biotechnology or a related field and have published previously in peer-reviewed journals. Knowledge in single-cell RNA-seq, laboratory automation and data analysis and/or Drosophila genetics is an advantage. The candidate should be able to work independently and also have excellent team working skills. The position further requires organizational qualifications and the ability to communicate effectively with internal and external collaborators. An excellent written and oral command of English is essential.
The application shall include a CV, a letter of motivation, degree certificates, and names and contact information of at least two references.
- Interesting, versatile workplace
- International, attractive working environment
- Campus with modern state-of-the-art infrastructure
- Salary according to TV-L including social benefits
- Possibility to work part-time
- Flexible working hours
- Comprehensive further training program
- Access to the DKFZ International Postdoc Program
The DKFZ is subject to the regulations of the Infection Protection Act (IfSG). As a consequence, only persons who present proof of immunity against measles as well as against COVID-19 may work at the DKFZ.
Earliest possible start date: as soon as possible
Duration: The position is initially limited to 2 years with the possibility of prolongation.
The position can in principle be part-time.
Application deadline: 13.10.2022
Prof. Dr. Michael Boutros
Phone +49 (0)6221/42-1950
Please note that we do not accept applications submitted via email.