Position: Computational Biologist

Department: Mechanisms Regulating Gene Expression

Code number: 2022-0362

The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.

Our Division of Mechanisms Regulating Gene Expression is currently seeking a motivated computational analyst to join an interdisciplinary project studying the function of RNA modifications in cancer development, metastasis and therapy resistance.


Job description:

Our project addresses the question how RNA modifications dynamically control transcription and mRNA translation when cancer cells are exposed to a new environment during metastasis or cancer treatment regimens for example. We utilize a wide array of biochemical, cellular, computational and in vivo approaches to identify novel epitranscriptomic key players but a major part will be the integration of nanopore sequencing approaches for full-length transcript analyses and base modification detection.

You will be responsible for leading and performing analysis as well as building computational models at the intersection of fast-evolving areas of RNA biology and translational research.

Working as part of a supportive and collaborative team, you will formulate and pursue translational science questions based on large data sets. You will curate, manage and perform high quality data analysis and provide feedback to other computational and wet lab scientists.



  • Candidates must have a master's degree and PhD degree in a relevant quantitative discipline (e.g. computational biology, genetics, bioinformatics, physics, engineering or applied statistics / mathematics) as well as a proven understanding and experience in the fields of genomics, data processing and high-throughput data analysis
  • Experience with programming in high level scripting languages (R and/or Python)
  • Demonstrated expertise in the management and analysis of very large data sets
  • Experience in writing manuscripts for publication
  • Strong communication skills, high level of organizational skills, and a logical and diligent approach to gathering information

We offer:

  • Interesting, versatile workplace
  • International, attractive working environment
  • Campus with modern state-of-the-art infrastructure
  • Salary according to TV-L including social benefits
  • Possibility to work part-time
  • Flexible working hours
  • Comprehensive further training program

Important notice:

The DKFZ is subject to the regulations of the Infection Protection Act (IfSG). As a consequence, only persons who present proof of immunity against measles as well as against COVID-19 may work at the DKFZ.

Earliest Possible Start Date: as soon as possible

Duration: The position is initially limited to 1 year.

The position can in principle be part-time.

Application Deadline: 11.10.2022


Dr. Michaela Frye
Phone +49 6221/42-4165

Please note that we do not accept applications submitted via email.

The DKFZ is committed to increase the proportion of women in all areas and positions in which women are underrepresented. Qualified female applicants are therefore particularly encouraged to apply.

Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.

To apply for a position please use our online application portal (https://www.dkfz.de/en/stellenangebote/index.php).

We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebsforschungszentrum, Personalabteilung, Im Neuenheimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apologize for any inconvenience this may cause.