Position: PhD Position (Physics, Chemistry, or similar) on Parahydrogen-Based Hyperpolarization for MRI of Cancer Metabolism
Department: DKTK Freiburg - Medical Physics, Department of Radiology, University Medical Center Freiburg
Code number: 2022-0402
The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.
Together with university partners at seven renowned partner sites, we have established the German Cancer Consortium (DKTK).
At the partner site of DKTK Freiburg the German Cancer Research Center is offering a PhD position in metabolic and molecular magnetic resonance imaging, oncology research, and parahydrogen-based hyperpolarization.
Cancer is associated with characteristic alterations in metabolism and other biological and functional properties. Precise imaging thereof promises improved diagnostics and therapy planning. Hyperpolarized MRI enables radiation-free mapping of such changes in living organisms by enhancing the MRI signal by several orders of magnitude. Bridging the gap between nuclear spin physics, organic chemistry, and medical diagnostics, hyperpolarization is a truly interdisciplinary research field. The Freiburg group focuses on the investigation and development of new hyperpolarization methods and bringing these advances to biomedical application with an ultimate goal of clinical translation.
This project will be focusing on the development and preclinical application of fast and cost-efficient hyperpolarization techniques and new agents to investigate tumor tissue. It will be conducted in close cooperation with our national partners from Heidelberg, Munich, and Tübingen and our US partners from Detroit (MI) to develop the next generation of molecular imaging for future cancer patient care.
Our asspiration is to combine physics and chemistry with applications improve cancer diagnosis and monitoring for personalized therapy in an emerging field of research.
- Developing hardware and polarizer setups
(fluidics of gases and liquids, reactor design, prototyping)
- Investigating hyperpolarization of new agents for metabolic and functional imaging of cancer
- Investigate the Signal Amplification By Reversible Exchange (SABRE) hyperpolarization technique and the purification to extract hyperpolarized agents in neat water
- First preclinical applications and oncology research
- Master's degree in physics, chemistry or similar
- Fluent English (in word and speech)
- Good scientific presenting and writing skills
- Solid background in molecular physics / chemistry
- Ideally experience with NMR or MRI
- Interesting, versatile workplace
- International, attractive working environment
- Campus with modern state-of-the-art infrastructure
- Access to international research networks
- Doctoral student payment including social benefits
- Flexible working hours
- Comprehensive training and mentoring program through the Helmholtz International Graduate School
The DKFZ is subject to the regulations of the Infection Protection Act (IfSG). As a consequence, only persons who present proof of immunity against measles as well as against COVID-19 may work at the DKFZ.
Earliest Possible Start Date: 01.01.2023
Duration: The position is limited to 3 years.
Application Deadline: 23.12.2022
Dr. Andreas Schmidt
Phone 0761 270 22810
Please note that we do not accept applications submitted via email.