Position: Postdoc in Computational Biology

Department: Pediatric Neurooncology at DKFZ and KiTZ

Code number: 2022-0483

The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.

The Hopp Children's Cancer Center Heidelberg (KiTZ) is a joint institution of the German Cancer Research Center (DKFZ), the Heidelberg University Hospital (UKHD) and the University of Heidelberg (UniHD). As a treatment and research center for oncological and hematological diseases in children and adolescents, the KiTZ is committed to scientifically explore the biology of childhood cancer and to closely link promising research approaches with patient care – from diagnosis to treatment and aftercare.

The Division of Pediatric Neurooncology at the German Cancer Research Center and the Hopp Children's Cancer Center Heidelberg is offering a postdoc position in computational biology.

 

Job description:

Treatment resistance is a major problem in cancer. Bone and soft tissue tumors – known as sarcomas – in adolescents and young adults often stop responding to treatment. This is because cancer cells develop many new characteristics during the disease progression to become resistant to effective drugs. The interdisciplinary research consortium HEROES-AYA aims to discover how sarcomas' cellular heterogeneity and molecular mechanisms lead to treatment resistance. The researchers hope to obtain fundamental insights into the development of treatment resistance in tumors and potentially identify options for novel therapeutic approaches.

The project is being led by scientists from DKFZ, the National Center for Tumor Diseases (NCT) Heidelberg and Dresden, and the Hopp Children's Cancer Center Heidelberg (KiTZ) and involves 12 research institutions. As part of the National Decade Against Cancer, the German Federal Ministry of Education and Research (BMBF) is providing more than 18 million euros to fund the project for five years.

As part of the initial diagnostic process in sarcoma patients, tissue samples of the tumor are taken, with further biopsies planned at later points in the course of the disease. This tumor material is subjected to highly detailed molecular profiling analysis of genome, genetic activity, epigenetics, and protein composition, analyzed at the level of individual cells. A total of 600 tumor samples from 220 patients will be analyzed at single-cell resolution.

For more info:

https://www.dkfz.de/en/presse/pressemitteilungen/2021/dkfz-pm-21-61-bone-and-soft-tissue-tumors-in-adolescents-as-a-model-system.php

https://www.kitz-heidelberg.de/en/research/research-groups/

 

Requirements:

We are seeking to appoint a highly motivated postdoctoral computational researcher responsible for conducting detailed analyses of single-cell sequencing datasets. This is an exciting opportunity to work on large-scale integration of single-cell-omics and clinical data to understand new biological insights into the treatment resistance mechanisms. The postholder will develop methodologies / platforms for data analysis, interpretation, and visualization for (epi)genome of individual cells, including the determination of somatic mutations per cell and the resulting phylogenies to better understand tumor evolution and tumor heterogeneity.

The applicants must hold a master's degree and a PhD (or equivalent) in bioinformatics, computational biology, genomics and biostatistics, computer science or a related subject. They should have strong analytical skills and broad experience with multiple programming languages (e.g., C++, Python, R, and Bash). The applicants must be proficient in Linux / Unix command lines. Basic knowledge of bioinformatics software and databases is essential. Experience in working in machine learning and high-performance computing environments is beneficial. It is a plus if they have expertise in the analysis and integration of next-generation sequencing and other multi-omics data, ideally including single-cell or single nucleus analysis and have a strong interest in oncology. Excellent communication and organization skills and proficiency in English are mandatory.

Applicants should be highly motivated, hard-working team players who enjoy working in an international team and are passionate about making a difference through cancer research. Close interdisciplinary cooperation with project partners of the HEROES-AYA project is expected from the postholder.

We offer:

  • Interesting, versatile workplace
  • International, attractive working environment
  • Campus with modern state-of-the-art infrastructure
  • Salary according to TV-L including social benefits
  • Possibility to work part-time
  • Flexible working hours
  • Comprehensive further training program
  • Access to the DKFZ  International Postdoc Program

Important notice:

The DKFZ is subject to the regulations of the Infection Protection Act (IfSG). As a consequence, only persons who present proof of immunity against measles may work at the DKFZ.

Earliest possible start date: as soon as possible

Duration: The position is initially limited to 2 years with the possibility of prolongation. ‚Äč

The position can in principle be part-time.

Application deadline: 09.02.2023

Contact:

Dr. Supat Thongjuea
Phone +49 (0)15201091154

Please note that we do not accept applications submitted via email.

The DKFZ is committed to increase the proportion of women in all areas and positions in which women are underrepresented. Qualified female applicants are therefore particularly encouraged to apply.

Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.

To apply for a position please use our online application portal (https://www.dkfz.de/en/stellenangebote/index.php).

We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebsforschungszentrum, Personalabteilung, Im Neuenheimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apologize for any inconvenience this may cause.