Position: Postdoctoral Researcher - Medicinal Chemistry & Chemical Biology

Department: Cancer Drug Development

Code number: 2024-0138

The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.

In the Cancer Drug Development group, we are interested in the synthesis and biological evaluation of novel chemical entities for use in cancer research and treatment. For the advertised position, we are seeking an experienced organic chemist to design and synthesize PROTACs against a specific protein target in an internal collaboration project.


Job description:

The synthesized substances will be biologically characterized in our collaborator's department at the DKFZ, which has specific expertise regarding this therapeutic target. Biological experiments can be conducted by the candidate themselves or by members of the other department, dependent upon the desire of the candidate (training will be offered). Regardless, the candidate will largely perform complex organic synthesis, but also dive deeply into cancer biology topics. Day to day tasks will entail detailed reading of the literature, planning, execution, optimization and analysis of multi-step reaction sequences, presentation of results in group meetings and conferences, writing of grant proposals and publications and supervision of students/technicians.


  • Highly motivated and creative individual with a PhD or related experience in synthetic organic chemistry
  • Ability to work on mg or multi-gram scale
  • Experience in retrosynthetic analysis, Schlenk technique and standard means of purification (chromatography, crystallization, distillation, HPLC)
  • Experience in analyzing NMR (1D and 2D) and MS spectroscopic data
  • Applicants with additional experience in biochemistry and chemical biology (e.g. enzyme kinetics, cell culture, gels, blotting techniques) are also desired
  • Ability to clearly communicate ideas verbally and at the white-board
  • Very good knowledge in verbal and written English

Your application should include a CV with publication list, two references, a brief summary of your past research and a copy of your Master's (or most recent degree) grades.

We offer:

  • Interesting, versatile workplace
  • Excellent framework conditions: state-of-the-art equipment and opportunity for international networking at the highest level
  • Remuneration according to TV-L incl. occupational pension plan for the public service and capital-forming payments
  • 30 days of vacation per year
  • Flexible working hours
  • Possibility of part-time work
  • Family-friendly working environment, including parent-child room, counseling services, e.g. on Elder Care
  • Sustainable travel to work: subsidized Germany job ticket
  • Develop your full potential: access to the DKFZ International Postdoc Program and DKFZ Career Service with targeted offers for your personal development to further develop your talents
  • Our Corporate Health Management Program offers a holistic approach to your well-being

Important notice:

The DKFZ is subject to the regulations of the Infection Protection Act (IfSG). As a consequence, only persons who present proof of immunity against measles may work at the DKFZ.

Earliest possible start date: as soon as possible

Duration: The position is initially limited to 2 years with the possibility of prolongation. ‚Äč

Application deadline: 31.05.2024


Dr. Aubry Miller
Phone +49 (0)6221/42-3307

Please note that we do not accept applications submitted via email.

The DKFZ is committed to increase the proportion of women in all areas and positions in which women are underrepresented. Qualified female applicants are therefore particularly encouraged to apply.

Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.

To apply for a position please use our online application portal (https://www.dkfz.de/en/stellenangebote/index.php).

We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebsforschungszentrum, Personalabteilung, Im Neuenheimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apologize for any inconvenience this may cause.