Bioinformatician

Reference number: 2025-0297

• Dresden
• Full-time
• NCT Dresden - Translational Medical Oncology

The German Cancer Research Center (DKFZ) is one of Europe’s largest cancer research centers. “Research for a life without cancer" is the mission of our world-class scientists and all our team members.

The DKFZ is a place where the brightest minds pursue bold ideas and seek answers to pioneering scientific questions through collaboration, innovation, and exploration across many disciplines. We provide a dynamic environment which empowers excellence with state-of-the-art technologies, cutting edge infrastructure, and a global scientific network. 

Contribute your knowledge, vision, and dedication to create a space where scientific discovery in cancer research is transformed into benefits for human health.

The National Center for Tumor Diseases (NCT) is a long-term cooperation between the German Cancer Research Center DKFZ, excellent partners in university medicine and other research institutions at six locations in Germany. The goal of the NCT is to bring promising results from cancer research into clinical application quickly and safely. This approach is intended to provide cancer patients with nationwide access to innovative treatment options.

One of the six NCT sites is the NCT Dresden (NCT/UCC), which is a collaboration between the DKFZ, the University Hospital Carl Gustav Carus Dresden (UCC), the Carl Gustav Carus Medical Faculty of the TU Dresden and the Helmholtz Center Dresden-Rossendorf (HZDR).

For the Department of Translational Medical Oncology at the NCT site Dresden, we are seeking for the next possible date a 

  NCT and DKFZ have laid the groundwork to address new challenges in personalized oncology through the MASTER program. This prospective registry trial employs very comprehensive molecular profiling and integrated data analysis (WGS/WES, RNA sequencing, genome-wide DNA methylation profiling; whenever possible, mass spectrometry-based (phosphor)proteomics, ex vivo drug sensitivity profiling, and spatial resolution of the immune environment). Based on the MASTER workflow, we provide clinically relevant management recommendations in a multicenter molecular tumor board (MTB) and follow up on clinical management of patients. The resulting multidimensional clinical and molecular dataset has kick-started very successful interdisciplinary research projects (e.g., Heining et al. Cancer Discov 2018, Gröschel et al. Nat Commun 2019, Horak et al. Cancer Discov 2021, Möhrmann et al. Nat Commun 2022, Jahn et al. Ann Oncol 2022).

Your Tasks

The Department of Translational Medical Oncology investigates the molecular and cellular mechanisms for cancer development, proliferation, and evolution. To strengthen our expertise in bioinformatics and machine learning, we are offering a position for a highly motivated scientist with significant experience in bioinformatics, ideally in the field of cancer research. You will be given the opportunity to develop your own research profile and standing in precision oncology and are expected to support the department’s research projects as well as write your own grant applications. The position is integrated in a multidisciplinary team of clinicians, scientists, and bioinformaticians and offers access to the MASTER dataset. As a successfull applicant, you will drive your own research, analyze NGS and other high-throughput data from patient cohorts and work on the development of improved NGS data analysis algorithms and design novel applications, e.g., for the integration of different data types.

Your Profile

• Significant expertise in bioinformatics or/and life sciences, with an excellent background in NGS analysis and relevant experience in the field, ideally with a PhD
• Background knowledge in cancer genomics
• Proficiency in Bash scripting and R and experience with cloud computing (required)
• Proficiency in Python and Git (preferred)
• Ability to perform bioinformatic and statistical analyses of multi-tier molecular profiling data, including NGS and single-cell NGS, and drive the development and implementation of new technologies
• High level of self-motivation and the ability to develop and pursue research projects independently as well as in collaboration
• Excellent written and spoken English skills and strong communication skills

Applications should include a CV, cover letter, certificates, expected availability date, a complete list of publications and 2-3 references.

We Offer

Are you interested?

 Then become part of the DKFZ and join us in contributing to a life without cancer!

 ​Duration: The position is initially limited to 2 years with the possibility of prolongation.

Application Deadline: 16.12.2025

Applications by e-mail cannot be accepted.

Please also note that we cannot return applications submitted by post.

 

We are convinced that an innovative research and working environment thrives on the diversity of its employees. Therefore, we welcome applications from talented people, regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical ability, religion and age. People with severe disabilities are given preference if they have the same aptitude.

Notice: We are subject to the regulations of the Infection Protection Act (IfSG). Therefore, all our employees must provide proof of immunity against measles.

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