Position: Postdoctoral researcher in the field of computational cancer epigenetics
Department: Cancer Epigenomics
Code number: 2019-0299
The German Cancer Research Center is the largest biomedical research institution in Germany. With approximately 3,000 employees, we operate an extensive scientific program in the field of cancer research.
The Division of Cancer Epigenomics at the German Cancer Research Center (DKFZ) is searching for a postdoctoral fellow to strengthen its computational team. The division conducts a rich and vibrant research program in epigenomics of several cancer entities, focusing on leukemias, several solid tumor types, such as prostate, breast and lung, as well as certain rare bone neoplasms. We generate a wide range of epigenetic profiles in tumors, both bulk and single-cell: including DNA methylomes, chromatin accessibility and histone modification patterns, genomic contact maps etc. Bioinformatically, we develop a novel computational methodology and user-friendly tools to enable comprehensive analysis of epigenomic data from multiple angles.
The project will involve the development of reproducible analysis workflows for multiple types of epigenomic data generated in the Division, both bulk and single-cell. Benchmarking studies will be conducted to devise the most accurate and computationally efficient procedures, in particular for the bisulfite sequencing data, as well as for Nanopore sequencing applied to DNA methylation profiling. The analysis workflows will be implemented using a standardized specification (CWL) and executed in hybrid HPC/cloud environments. The successful candidate will then perform comprehensive high-level integration analyses of epigenetic data to gain novel insights into the biology of several types of cancer, as well as adipogenesis and osteogenesis.
Applicants should have a master's degree and a Ph.D. degree in computational biology, bioinformatics or related discipline, with a solid mathematical/computational background and proven track record of methods development for life-science applications. Fluency in one of the standard scripting languages (Python, Perl or alike) as well as experience with R is preferred, but not a must, should the candidate be proficient in any other general domain-specific languages (e.g., C/C++, Java or Matlab). We expect basic knowledge of Unix-like operating systems and respective command line interface (bash scripting) and ability to work in typical HPC environment setups (schedulers, cloud environments etc.). Previous experience with epigenomic data or cancer research applications is an advantage.
- Interesting, versatile workplace
- International, attractive working environment
- Campus with modern state-of-the-art infrastructure
- Salary according to TV-L including social benefits
- Possibility to work part-time
- Flexible working hours
- Comprehensive further training program
- Access to the DKFZ International Postdoc Program
Earliest possible start date: as soon as possible
Duration: The position is limited to 2 years with the possibility of prolongation.
The position can in principal be part-time.
Application deadline: 04.10.2019
Dr. Pavlo Lutsik
Phone +49 6221/42-4322
Please note that we do not accept applications submitted via email.