Position: Postdoc – Single Cell Technologies
Department: Signaling and Functional Genomics
Code number: 2019-0300
The German Cancer Research Center is the largest biomedical research institution in Germany. With approximately 3,000 employees, we operate an extensive scientific program in the field of cancer research.
The Boutros Group / Division of Functional Genomics and Signaling at the German Cancer Research Center (DKFZ) is seeking a highly motivated postdoctoral fellow to lead the development and application of novel single cell methodologies. The project has the aim to create perturbation-based genetic maps at the level of individual cells by using single cell sequencing technologies. The position is funded by the new ERC Synergy Project DECODE, a close collaboration between DKFZ, EMBL and Heidelberg University.
The evolutionary success of multicellular organisms is based on the division of labor between cells. While some of the molecular determinants for cell fate specification have been identified, a fundamental understanding of which genetic activities are required in each cell of a developing tissue is still outstanding. The ERC DECODE project develops and applies leading-edge system genetics methods to decode context-dependent genetic networks in vivo. To achieve this, DECODE will bring together experimental and theoretical groups with complementary expertise in model organism genetics and cellular phenotyping, single-cell genomics, statistics and computational biology. Building on our combined expertise of the ERC Synergy groups, we will create functional genetic maps using conditional CRISPR/Cas9-based single- and higher order knockout perturbations combined with single-cell expression profiling and imaging. We expect that this project will advance new experimental approaches and will provide fundamental insights into the cellular circuitries that govern many processes in a metazoan organism. The particular focus of the postdoctoral position will be on the development, automation and application of single cell methodologies for perturbation-based analyses.
We are looking for a highly motivated postdoctoral researcher, preferably with a strong background in the development of single cell technologies, CRISPR, high-throughput technologies and molecular biology. Candidates should have an advanced academic degree (PhD) in biology, biochemistry, biotechnology or related field and have published previously in peer-reviewed journals. Knowledge in single-cell RNA-seq, laboratory automation and data analysis is an advantage. The candidate should be able to work independently and also have excellent team working skills. The position further requires organizational qualifications and the ability to communicate effectively with internal and external collaborators. An excellent written and oral command of English is essential.
The application shall include a CV, a letter of motivation, degree certificates and names and contact information of at least two references.
- Interesting, versatile workplace
- International, attractive working environment
- Campus with modern state-of-the-art infrastructure
- Salary according to TV-L including social benefits
- Possibility to work part-time
- Flexible working hours
- Comprehensive further training program
- Access to the DKFZ International Postdoc Program
Earliest possible start date: as soon as possible
Duration: The position is limited to 2 years with the possibility of prolongation.
The position can in principal be part-time.
Application deadline: 17.10.2019
Prof. Dr. Michael Boutros
Phone +49 (0)6221/42-1951
Please note that we do not accept applications submitted via email.