Department: Clinical Cooperation Unit Pediatric Oncology
Code number: 2019-0330
The German Cancer Research Center is the largest biomedical research institution in Germany. With approximately 3,000 employees, we operate an extensive scientific program in the field of cancer research.
We have an opening for a postdoctoral position in the group "Translational brain tumor modeling" (group leader: PD Dr. Till Milde) with a focus on drug target development for the therapy of pediatric tumors with DNA damage repair defects (DDRD).
The group is located within the Clinical Cooperation Unit (CCU) Pediatric Oncology (headed by Prof. Dr. med. Olaf Witt) and affiliated to the Hopp Children’s Cancer Center (KiTZ), a joint venture of the German Cancer Research Center (DKFZ) and the Medical Faculty of Heidelberg University. We focus on the development of pediatric brain tumor models and drug target development. Ultimately, we aim at the improvement of treatment outcome by developing novel therapeutic approaches for pediatric brain tumors.
The postdoc will be working on the drug target development in DDR defective pediatric tumors, developing clinical relevant PDX models and performing drug screens. This will include writing of in vivo experiments applications. The project is embedded in the national ADDRess consortium (Translational research for persons with abnormal DNA damage response). The ADDRess consortium is a collaborative network of leading national groups in the DDR field and aims at improving molecular diagnostics, detection, counselling, surveillance and treatment of patients with DDRD. The goals of the specific project are to a) establish novel patient-derived xenograft (PDX) models of and b) discover novel drug-based approaches to the treatment for DADDR. A strong characteristic of our group and the project in particular is an intensive interaction with all groups working in the ADDRess consortium, the KiTZ and with cooperating national and international groups in the field.
We are looking forward to receive applications from highly motivated scientists. Applicants should hold a PhD in biology or a related field, with a track record of publications in peer-reviewed journals. Applicants should ideally have a documented strong expertise in DDRD, primary tumor tissue culture, drug target development, drug screening, cancer signaling, as well as animal application writing and in vivo (mouse) experience.
The scientist on this position is expected to work independently but collaboratively with other lab members as well as with other pediatric cancer research groups. An excellent communication skill for scientific discussion is indispensable and proficiency in English is mandatory.
Full applications should include a curriculum vitae, a letter of motivation, certificates, expected availability date, a list of publications and 2-3 references.
- Interesting, versatile workplace
- International, attractive working environment
- Campus with modern state-of-the-art infrastructure
- Salary according to TV-L including social benefits
- Possibility to work part-time
- Flexible working hours
- Comprehensive further training program
- Access to the DKFZ International Postdoc Program
Earliest possible start date: as soon as possible
Duration: The position is limited to 2 years with the possibility of prolongation.
The position can in principle be part-time.
Application deadline: 19.11.2019
Dr. Till Milde
Phone +49 (0)6221/42-3575
Please note that we do not accept applications submitted via email.