Position: 2 PhD student positions
Department: Cell Cycle Control and Carcinogenesis
Code number: 2019-0342
The German Cancer Research Center is the largest biomedical research institution in Germany. With approximately 3,000 employees, we operate an extensive scientific program in the field of cancer research.
The PhD project is focused on the interplay between the formation of focal adhesions (FA) and the organization of the mitotic spindle apparatus in metastatic breast cancer.
Breast cancer is the most frequently diagnosed form of cancer and the second leading cause of cancer-related deaths among women worldwide. Correct spindle orientation is achieved through signaling pathways that provide a molecular link between the cell cortex and spindle microtubules in an F-actin-dependent manner (Zhu et al., J Cell Biol 2013, 200, 773-787; Kschonsak and Hoffmann, J Cell Sci 131, 2018). Mitotic spindle orientation abnormalities and loss of cell adhesion, have been proposed to facilitate cancer invasion and metastasis, yet the molecular mechanisms underlying these processes are largely unknown. To study the interplay between the two processes we will use ex vivo breast cancer models that show different characteristics in response to their invasion and metastatic properties.
Applicants should hold a master’s degree in biology / life sciences with excellent grades, background in cellular and molecular biology and have strong laboratory and analytical skills. Please send your CV, research interests, copies of certificates, transcript of records from high school, bachelor and master studies, your research interests and contact addresses of two referees to Ingrid.Hoffmann@dkfz.de.
Further information about our team at http://www.dkfz.de/en/f045/index.php
- Interesting, versatile workplace
- International, attractive working environment
- Campus with modern state-of-the-art infrastructure
- Access to international research networks
- Doctoral student payment including social benefits
- Flexible working hours
- Comprehensive training and mentoring program through the Helmholtz International Graduate School
Earliest Possible Start Date: as soon as possible
Duration: The position is limited to 3 years.
Application Deadline: 30.11.2019
Prof. Dr. Ingrid Hoffmann
Phone +49 (0)6221/42-4908
Please note that we do not accept applications submitted via email.