Position: Postdoctoral Research Fellow
Department: Neural Stem Cell Genome Integrity in Brain Development and Diseases
Code number: 2019-0372
The German Cancer Research Center is the largest biomedical research institution in Germany. With approximately 3,000 employees, we operate an extensive scientific program in the field of cancer research.
Together with the University of Heidelberg, the National Center for Tumor Diseases (NCT), and German Consortium of Translational Cancer Research (DKTK), the DKFZ provides an outstanding research environment that fully supports fundamental and translational research. Our research group is embedded within the DKFZ and the University of Heidelberg, both world-renowned institutions for cancer research. As part of the Helmholtz program of Cancer Research, we aim to unravel the causes and mechanisms of cancer development and, based on new insights, to develop novel tools for diagnosis, early detection, treatment, and prevention of cancer. For more information, please visit www.dkfz.de.
Neural progenitor cells undergo tens of thousands of cell divisions to generate the 80 billion neurons in a human brain. Mild gene malfunction occurring to a low number of neurons is sufficient to impair the neuron network and lead to brain malfunctions. Recently, we found that in neural stem cells, a group of genes encoding neuronal synaptic proteins harbor recurrent DNA breaks. Inactivation of DNA break-containing genes is strongly associated with neuropsychiatric disorders and cancers. Our mission is to understand the source and function of the recurrent DNA breaks and the roles of DNA breaks in brain diseases.
Your task is to investigate the fate of neural stem cells, which harbor recurrent DNA breaks. To this end, you will generate and characterize mouse models, manage mouse colonies, and generate and analyze the next-generation sequencing data. You will be working in a highly collaborative and interdisciplinary environment.
- Ph.D. degree in biology or equivalent
- Good practice in mammalian cell culture, gene editing, and mouse models
- Background in computational biology is not necessary but is a plus
You should be:
- eager to explore the frontiers of science
- dedicated, responsible and motivated
- used to work in a collaborative environment
- proficient in English; knowledge of German is not required but is a plus
- Interesting, versatile workplace
- International, attractive working environment
- Campus with modern state-of-the-art infrastructure
- Salary according to TV-L including social benefits
- Possibility to work part-time
- Flexible working hours
- Comprehensive further training program
- Access to the DKFZ International Postdoc Program
Earliest possible start date: as soon as possible
Duration: The position is limited to 2 years with the possibility of prolongation.
The position can in principle be part-time.
Application deadline: 23.12.2019
Dr. Pei-Chi Wei
Phone +49 6221/42-3251
Please note that we do not accept applications submitted via email.