Position: PhD Student - Vascular Signaling and Cancer
Department: Vascular Signaling and Cancer
Code number: 2020-0224
The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.
The Division of Vascular Signaling and Cancer is seeking a highly motivated PhD student. Our research interest is signaling transduction in endothelial cells and the consequences on the biology of cancer cells and adipose tissue. We have very recently shown that endothelial Notch signaling not only controls angiogenesis but also the transport of fatty acids, glucose and insulin across the blood vessel wall (Jabs, Circulation, 2018, Hasan, EMBO Mol Med 2020) and the dissemination of tumor cells (Wieland, Cancer Cell, 2017). Further information is available on our DKFZ webpage (http://www.dkfz.de/en/vaskulaere-signaltransduktion/index.php).
The aim of this third part-funded project is to functionally characterize how endothelial cells control adipose tissue under normal and disease conditions. This is of utmost importance as adipose tissue is critically involved in chronic inflammation and tumor progression. The successful candidate will use cell culture and animal models to address how disease conditions alter the endothelial transcriptome and how this alters subsequently signaling and transcription in adipocytes. Finally, this project will allow to interfere with endothelial cell signaling in order to manipulate inflammation or tumor progression.
- Master’s degree in biology, biotechnology or similar
- 'hands on’ experience with basic laboratory techniques
- Experience in working with animals or a will to work with animals
- Highly motivated and well organized
- Good knowledge of the English language
The DKFZ is a world-leading institution in the field of applied and basic cancer research and offers an excellent research environment with state-of-the-art equipment and core facilities. The successful candidate will be given solid technical support and the possibility of training graduate students (if desired).
Please submit your application with a letter of motivation, CV, diploma and certificates, and contact information of 2-3 referees in a single PDF document.
- Interesting, versatile workplace
- International, attractive working environment
- Campus with modern state-of-the-art infrastructure
- Access to international research networks
- Doctoral student payment including social benefits
- Flexible working hours
- Comprehensive training and mentoring program through the Helmholtz International Graduate School
Earliest Possible Start Date: as soon as possible
Duration: The position is limited to 3 years.
Application Deadline: 23.09.2020
Prof. Dr. Andreas Fischer
Phone +49 (0)6221/42-4150
Please note that we do not accept applications submitted via email.