Position: PhD Student
Department: Cell Cycle Control and Carcinogenesis
Code number: 2020-0237
The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.
The PhD project is focused on the interplay between the formation of focal adhesions (FA) and the organization of the mitotic spindle apparatus in metastatic breast cancer.
Correct spindle orientation is achieved through signaling pathways that provide a molecular link between the cell cortex and spindle microtubules in an F-actin-dependent manner (Zhu et al., J Cell Biol 2013, 200, 773-787; Kschonsak and Hoffmann, J Cell Sci 131, 2018). Mitotic spindle orientation abnormalities and loss of cell adhesion, have been proposed to facilitate cancer invasion and metastasis, yet the molecular mechanisms underlying these processes are largely unknown. To study the interplay between the two processes we will use ex vivo breast cancer models that show different characteristics in response to their invasion and metastatic properties.
Further information about our team at http://www.dkfz.de/en/f045/index.php
Applicants should hold a diploma / master's degree in biology or life sciences with excellent grades, theoretical and experimental background in cellular biology and biochemistry and have strong laboratory and analytical skills.
To apply, please submit your CV, a motivational letter, a transcript of records from both bachelor's and master's studies, a document of high proficiency in spoken and written English and a list of contact addresses (e-mail or telephone numbers) of at least two referees via the online application portal (www.dkfz.de/jobs).
- Interesting, versatile workplace
- International, attractive working environment
- Campus with modern state-of-the-art infrastructure
- Access to international research networks
- Doctoral student payment including social benefits
- Flexible working hours
- Comprehensive training and mentoring program through the Helmholtz International Graduate School
Earliest Possible Start Date: 02.11.2020
Duration: The position is limited to 3 years with the possibility of prolongation.
Application Deadline: 29.09.2020
Prof. Dr. Ingrid Hoffmann
Phone +49 (0)6221/42-4908
Please note that we do not accept applications submitted via email.