Position: PhD Student
Department: NCT Dresden
Code number: 2018-0327
The German Cancer Research Center is the largest biomedical research institution in Germany. With approximately 3,000 employees, we operate an extensive scientific program in the field of cancer research.
The National Center of Tumor Diseases (NCT) Dresden is a joint institution of the German Cancer Research Center, the University Hospital Carl Gustav Carus Dresden, the Faculty of Medicine at TU Dresden, and the Helmholtz-Zentrum Dresden-Rossendorf (HZDR). The NCT with sites in Heidelberg and Dresden is the leading oncological center in Germany and shall be expanded to an international center of excellence regarding point-of-care and individualized cancer medicine.
The German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) offers a PhD position at the Dresden partner site in the research groups of Prof. Mechthild Krause and Prof. Anna Dubrovska located in OncoRay – The National Center for Radiation Research in Oncology, Dresden. We invite applications for a PhD student highly motivated to work in the field of translational bio-medicine to develop new immunotherapeutic approaches for tumor radiosensitization.
Our groups are working on identifying tumor biomarkers for radiation oncology which can be used to aid cancer prognosis and treatment. Biomarkers that are deregulated in cancer stem cells (CSC) are of special interest because they may be used to predict treatment outcome and serve as potential targets for cancer therapy.
This PhD project aims to validate CSC-related therapeutic targets and apply the combination of radiation with state-of-the-art immunotherapies using different in vitro and animal tumor models. In addition, immunohistochemical tissue staining and molecular profiling of the treated tumors will be analyzed. The position is embedded in a joint project between three groups with strong experience in radiation oncology (Prof. Mechthild Krause), radiation biology (Prof. Anna Dubrovska), and development of BiTEs and CAR T-cells (Prof. Michael Bachmann).
Peitzsch C et al., Cancer Res. 2016; 76(9):2637-51;
Linge A et al., Clin Cancer Res. 2016;22(11):2639-49;
Cojoc M et al., Cancer Res. 2015;75(7):1482-94;
Kurth I et al., Oncotarget 2015;6(33):34494-509.
Castro Nava A et al., Int J Cancer 2015;137(10):2492-503;
Kloss CC et al., Nature Biotechnology 2013; 31(1):71-5.
Further background can be found on OncoRay homepage: https://www.oncoray.de/research/translational-radiooncology-and-clinical-radiotherapy/
- Strong interest in tumor biology and translational radiooncology
- Master of science degree or equivalent in biology, biochemistry, biotechnology, molecular medicine or related fields
- Experience in molecular and cell biology techniques
- High motivation to work in ambitious, multi-disciplinary and international research group
- Ability to work independently, as part of a team and in collaboration with others
- Strong problem-solving skills and creative thinking
- Experience in working with laboratory animals (mice) is desirable but no essential
- Fluency in spoken and written English
- Interesting and motivating workplace;
- Arranging for flexible working hours to find a balance between work and family life;
- Taking part in job-oriented educational courses.
Prof. Anna Dubrovska, email@example.com
- Interesting, versatile workplace
- International, attractive working environment
- Campus with modern state-of-the-art infrastructure
- Access to international research networks
- Doctoral student payment including social benefits
- Flexible working hours
- Comprehensive training and mentoring program through the Helmholtz International Graduate School
Earliest Possible Start Date: ab 01.03.2019
Duration: The position is limited to 3 years.
Application Deadline: 01.02.2019
Phone +49 (0) 351 458 5239
Please note that we do not accept applications submitted via email.