Position: Postdoc in Tumor Immunology
Department: NCT Dresden - Junior Group Tumor Immunology
Code number: 2020-0339
The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.
The National Center for Tumor Diseases (NCT) Dresden is a joint institution of the German Cancer Research Center (DKFZ) Heidelberg, the University Hospital Carl Gustav Carus Dresden, the Faculty of Medicine at TU Dresden, and the Helmholtz-Zentrum Dresden-Rossendorf (HZDR). The NCT with sites in Heidelberg and Dresden is the leading oncological center in Germany and shall be expanded to an international center of excellence regarding point-of-care and individualized cancer medicine.
The German Cancer Research Center is seeking for the partner site Dresden of the National Center of Tumor Diseases a postdoctoral researcher on the topic tumor immunology.
The ability of neoplastic cells to attenuate the immune system and achieve immune resistance is a key step in tumorigenesis. Our research strives for the identification of new strategies for modulating immune resistance in cancer cells and translation of these results into innovative immunotherapies. We are specifically interested in the genetic repertoire required for the expression and maintenance of immune checkpoint proteins mediating resistance to CD8+ T lymphocytes. A successful candidate will apply methods of reverse genetics such as CRISPR/Cas9-based genome editing and RNA interference in human cancer cells to dissect the function and the regulation of immune checkpoint proteins utilizing loss-of-function screening. Some parts of the open project will be based on our recent publication on the regulation of the immune checkpoint protein PD-L1 (Sreevalsan et al., EMBO Reports, 2020, e50155).
We are looking for a dedicated and reliable scientist holding a PhD in molecular or cell biology with practical experience in tumor biology and immunology. Candidates with experiences in handling cytotoxic T lymphocytes and loss-of-function screening will be preferred. Experience in writing scientific publications and grants is of value. Successful candidates will be working in an international environment and proficiency in written and oral English is required.
Full applications should include a curriculum vitae, a cover letter (please state your research interest and your expected availability date), a PhD thesis overview, certificates and recommendation letters.
- Interesting, versatile workplace
- International, attractive working environment
- Campus with modern state-of-the-art infrastructure
- Salary according to TV-L including social benefits
- Possibility to work part-time
- Flexible working hours
- Comprehensive further training program
- Access to the DKFZ International Postdoc Program
Earliest possible start date: as soon as possible
Duration: The position is limited until 31.12.2022.
The position can in principle be part-time.
Application deadline: 31.01.2021
Phone +49 351/458-3372
Please note that we do not accept applications submitted via email.