Job description:

We are seeking exceptional candidates to fill a PhD position in the field of pediatric neurooncology. The project aims to identify synergistic treatment combinations against pediatric high-grade glioma. Initially, within a comprehensive screening approach, a library of clinically relevant small molecule inhibitors will be combined with modern radiation modalities to analyze the impact on growth and survival in a large collection of primary tumor cell cultures. Subsequently, promising combinations will be validated through additional in vitro and in vivo pre-clinical testing. The project involves a diverse range of tasks including in vitro studies in the S1 and S2 laboratory as well as work with mice, while utilizing state-of-the-art methodologies (novel therapeutics, CRISPR, high-throughput sequencing, autochthonous and transplantation-based animal models). Additionally, the PhD student will share common laboratory tasks and administrative duties with colleagues as part of a supportive team environment.

Requirements:

• Master’s degree in biology or similar field of study
• Initiative towards planning own and common tasks
• Experience with basic molecular biology techniques (cloning, DNA / protein extraction, Western Blot, cell culture etc.)
• Curiosity towards expanding scientific knowledge and new opportunities
• Fluent English
• Collegiality and ability to work well in a team
• Engagement and motivation for pursuing a research project from planning through to analysis and presentation of results
• Experience with preclinical models in vitro and/or in vivo is strongly preferred