Position: Postdoctoral Position in Cell Fate Engineering
Department: Junior Research Group Cell Fate Engineering and Disease Modeling
Code number: 2021-0123
The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.
The laboratory of the Junior Research Group „Cell Fate Engineering and Disease Modeling“ (headed by Dr. Moritz Mall) combines animal models, pluripotent stem cells, and genetic engineering to reconstruct and investigate human development and disease (Mall and Wernig, JMM 2017). Our mission is to understand the mechanisms that determine and maintain cell fate with the goal to treat diseases associated with loss of cell identity (Mall, Nature 2017; Lee and Mall, Nature Cell Bio 2020). Embedded within the Hector Institute of Translational Brain Research (HITBR) at the German Cancer Research Center (DKFZ) in Heidelberg our lab offers the unique opportunity to be part of our energetic and ERC-funded research team to work at the interface of stem cell biology, cancer and neuroscience at Germany’s largest biomedical research center.
Please visit https://www.dkfz.de/en/cell-fate-engineering/ for more information on our lab.
The project aims to investigate the transcriptional and epigenetic mechanisms that allow cell fate induction and maintenance with the goal to understand new principles of cell fate biology and to develop next-generation cell-based models to advance translational medicine. We believe that combining cell fate engineering and stem cell technologies has great potential to better understand complex human disorders and to identify strategies to treat these diseases in the future.
The successful candidate will be able to develop the research project using cutting-edge technologies such as cellular reprogramming and single cell genomics. The tasks include cell culture, biochemical as well as functional genomic screens using a wide range of innovative technologies and research infrastructure. The major goals are outline below:
- Design and develop cutting-edge research projects
- Create and characterize new cell reprogramming and mouse models
- Optimize human stem cell culture and genetic engineering approaches
- Develop novel 2 and 3D disease models using human stem cells
- Generate and analyze next-generation single cell functional genomics data
We are looking for a highly motivated recently graduated top-level PhD with a strong background in molecular or cell biology. Research experience in molecular cloning and functional genomic screens using animal and/or human pluripotent stem cells are desired. Skills in cell reprogramming and analysis of muscle, liver, cardiac or neurons using functional assays is meriting. The ambitious candidate should be driven to develop a research project using cutting-edge technologies and have:
- Demonstrated scientific productivity
- Excellent written and oral communication skills
- Very good organization skills and be a reliable team player
- Functional genomics data generation and analysis skills
- Hands-on single cell genomics experience
- Extensive cell culture practice
Applications should include a cover letter and a CV with a complete list of publications as well as contact details of 3 references.
- Interesting, versatile workplace
- International, attractive working environment
- Campus with modern state-of-the-art infrastructure
- Salary according to TV-L including social benefits
- Possibility to work part-time
- Flexible working hours
- Comprehensive further training program
- Access to the DKFZ International Postdoc Program
Earliest possible start date: as soon as possible
Duration: The position is limited to 2 years with the possibility of prolongation.
The position can in principle be part-time.
Application deadline: 20.05.2021
Dr. Moritz Mall
Please note that we do not accept applications submitted via email.