Position: Postdoctoral Position – Genetic Interactions and Synthetic Lethality in Cancer

Department: Signaling and Functional Genomics

Code number: 2021-0214

The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.

The research group "Signaling and Functional Genomics", headed by Prof. Dr. Michael Boutros at the German Cancer Research Center in Heidelberg, is interested in systematically analyzing developmental-oncogenic signaling pathways using a combination of experimental and computational approaches. Within this project, we aim to identify novel synthetic lethal factors that are potential targets for cancer therapy.  


Job description:

As part of our team, we are seeking a highly motivated postdoctoral candidate with an interest in interdisciplinary genomic research. The postdoctoral project will advance and apply technologies to identify synthetic lethal interactions using high-throughput cell-based CRISPR and chemico-genetic screens. The project builds on previous approaches in the lab  (Laufer et al. 2013; Breinig et al., 2015; Scheeder et al., 2018; Heigwer et al., 2018; Henkel et al., 2020) to identify genetic interactions using multiplexed imaging and pooled assays. We expect that this project will advance new experimental methods and will provide insights into synthetic lethal interactions that will be further studied using multi-omics and in-depth mechanistic analyses. The project will be part of a collaboration with GSK/Cellzome.



We are looking for a highly motivated postdoctoral fellow who has experience in cell biology and high-throughput genomic technologies. The candidate should have an academic degree (PhD or MD/PhD) in biology, biochemistry, biotechnology or a related field and have previously published in peer-reviewed journal. Expertise in the design and execution of CRISPR/Cas screening experiments and experience in the analysis of genomic experiments would be an advantage (e.g. R/Bioconductor skills). The candidate should be able to work independently and should have excellent team working skills. The position further requires excellent organizational capacities, the ability to communicate effectively and to build and maintain strong relationships with collaborators in academia and industry. An excellent written and oral command of English is essential.

The application shall include a cover letter stating your motivation, CV including publications and names and contact information of two references.

We offer:

  • Interesting, versatile workplace
  • International, attractive working environment
  • Campus with modern state-of-the-art infrastructure
  • Salary according to TV-L including social benefits
  • Possibility to work part-time
  • Flexible working hours
  • Comprehensive further training program
  • Access to the DKFZ  International Postdoc Program

Earliest possible start date: as soon as possible

Duration: The position is limited to 2 years with the possibility of prolongation.

The position can in principle be part-time.

Application deadline: 04.08.2021


Prof. Dr. Michael Boutros
Phone +49 (0)6221/42-1950

Please note that we do not accept applications submitted via email.

The DKFZ is committed to increase the proportion of women in all areas and positions in which women are underrepresented. Qualified female applicants are therefore particularly encouraged to apply.

Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.

To apply for a position please use our online application portal (https://www.dkfz.de/en/stellenangebote/index.php).

We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebsforschungszentrum, Personalabteilung, Im Neuenheimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apologize for any inconvenience this may cause.