Position: Postdoctoral Position – Genetic Interactions and Synthetic Lethality in Cancer
Department: Signaling and Functional Genomics
Code number: 2021-0214
The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.
The research group "Signaling and Functional Genomics", headed by Prof. Dr. Michael Boutros at the German Cancer Research Center in Heidelberg, is interested in systematically analyzing developmental-oncogenic signaling pathways using a combination of experimental and computational approaches. Within this project, we aim to identify novel synthetic lethal factors that are potential targets for cancer therapy.
As part of our team, we are seeking a highly motivated postdoctoral candidate with an interest in interdisciplinary genomic research. The postdoctoral project will advance and apply technologies to identify synthetic lethal interactions using high-throughput cell-based CRISPR and chemico-genetic screens. The project builds on previous approaches in the lab (Laufer et al. 2013; Breinig et al., 2015; Scheeder et al., 2018; Heigwer et al., 2018; Henkel et al., 2020) to identify genetic interactions using multiplexed imaging and pooled assays. We expect that this project will advance new experimental methods and will provide insights into synthetic lethal interactions that will be further studied using multi-omics and in-depth mechanistic analyses. The project will be part of a collaboration with GSK/Cellzome.
We are looking for a highly motivated postdoctoral fellow who has experience in cell biology and high-throughput genomic technologies. The candidate should have an academic degree (PhD or MD/PhD) in biology, biochemistry, biotechnology or a related field and have previously published in peer-reviewed journal. Expertise in the design and execution of CRISPR/Cas screening experiments and experience in the analysis of genomic experiments would be an advantage (e.g. R/Bioconductor skills). The candidate should be able to work independently and should have excellent team working skills. The position further requires excellent organizational capacities, the ability to communicate effectively and to build and maintain strong relationships with collaborators in academia and industry. An excellent written and oral command of English is essential.
The application shall include a cover letter stating your motivation, CV including publications and names and contact information of two references.
- Interesting, versatile workplace
- International, attractive working environment
- Campus with modern state-of-the-art infrastructure
- Salary according to TV-L including social benefits
- Possibility to work part-time
- Flexible working hours
- Comprehensive further training program
- Access to the DKFZ International Postdoc Program
Earliest possible start date: as soon as possible
Duration: The position is limited to 2 years with the possibility of prolongation.
The position can in principle be part-time.
Application deadline: 04.08.2021
Prof. Dr. Michael Boutros
Phone +49 (0)6221/42-1950
Please note that we do not accept applications submitted via email.