PhD Student on the topic “Delineation of metastatic drivers in gastric cancer”
Reference number: 2024-0379
- Dresden
- Full-time
- DKTK partner site Dresden - Junior Research Group "Forward Genetics for Translational Solid Cancer Research"
“Research for a life without cancer" is our mission at the German Cancer Research Center. We investigate how cancer develops, identify cancer risk factors and look for new cancer prevention strategies. We develop new methods with which tumors can be diagnosed more precisely and cancer patients can be treated more successfully. Every contribution counts – whether in research, administration or infrastructure. This is what makes our daily work so meaningful and exciting.
Together with university partners at seven renowned partner sites, the German Cancer Research Center (DKFZ) has established the German Cancer Consortium (DKTK).
For the Junior Research Group "Forward Genetics for Translational Solid Cancer Research" at the DKTK partner site Dresden, we are seeking for the next possible date a
In the Junior Research Group "Forward Genetics for Translational Solid Cancer Research", we study different cancer phenotypes, from resistance to therapy to metastatic competence. Physiologically relevant modeling systems are utilized, including mouse models and 3D organoid cultures. The unifying methodological framework are forward genetic screens that aim to delineate genetic determinants of a given phenotype. Our screens make use of a range of Cas9 modalities to mimic different patterns of gene expression. The ultimate goals are the identification of drivers of therapy resistance and metastasis and, consequently, the development of new therapeutics to target these processes.
Your Tasks
- Perform an in vivo CRISPR screen to identify metastasis drivers in gastric cancer
- Functional investigation of hits through omics approaches
- Validation of genes mediating metastasis in an in vivo model
- Work in cooperation with clinicians, computational biologists, and genetic engineering experts
Your Profile
- Master's degree in biology, biotechnology, biomedicine or related fields
- Previous experience in working with mice
- Familiarity with cancer biology, especially cancer genomics
- Expertise in mammalian cell culture; familiarity with 3D culture is a bonus
- Basic skills in molecular biology techniques such as cloning, nucleic acid isolation, PCR, Western blot
- Familiarity with basic CRISPR techniques
- Strong commitment and motivation to work independently
- Desire to perform in an international and dynamic team
- Fluency in spoken and written English
We Offer
Excellent framework conditions: state-of-the-art equipment and opportunities for international networking at the highest level
Access to international research networks
Doctoral salary with the usual social benefits
30 days of vacation per year
Flexible working hours
Possibility of part-time work
Family-friendly working environment
Sustainable travel to work: subsidized Germany job ticket
Unleash your full potential: targeted training and mentoring through the DKFZ International PhD Program and DKFZ Career Service
Our Corporate Health Management Program offers a holistic approach to your well-being
Are you interested?
Then become part of the DKFZ and join us in contributing to a life without cancer!
Dr. Jovan Mircetic
Phone: +49 351 4582391
We are convinced that an innovative research and working environment thrives on the diversity of its employees. Therefore, we welcome applications from talented people, regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical ability, religion and age. People with severe disabilities are given preference if they have the same aptitude.
