Postdoctoral Scientist in Radiopharmaceutical Development – Radiochemist/Radiopharmacist in part-time (50%)

Reference number: 2025-0171

• Heidelberg
• Part time 19,75 h/week
• Junior Research Group "Translational Radiotheranostics"

“Research for a life without cancer" is our mission at the German Cancer Research Center. We investigate how cancer develops, identify cancer risk factors and look for new cancer prevention strategies. We develop new methods with which tumors can be diagnosed more precisely and cancer patients can be treated more successfully. Every contribution counts – whether in research, administration or infrastructure. This is what makes our daily work so meaningful and exciting.

The Junior Research Group "Translational Radiotheranostics" is seeking for the next possible date a

  In the 21st century, cancer will remain one of the leading causes of death worldwide. Our mission is to prevent this through the promising combination of personalized radiodiagnostics and targeted radionuclide therapy – known as radiotheranostics.

The ideal candidate will join the independent Junior Research Group “Translational Radiotheranostics” and is expected to pursue a highly innovative project at the frontiers of interdisciplinary cancer research. The position would start at 50%, with a possible extension to 100% later.

Your Tasks

• Development of novel small-molecule and peptide-based radioligands for diagnostic, therapeutic, and theranostic applications; this includes rational drug design based on structure-activity relationships, synthetic route development, and comprehensive chemical and radiochemical characterization
• Radiolabeling of compounds with a broad spectrum of medically relevant radionuclides, including alpha-emitters, beta-emitters, and gamma-emitters
• Optimization of labeling protocols and evaluation of complex stability, radiochemical purity, and shelf-life under physiological conditions
• Functional characterization of radiolabeled compounds using a variety of in vitro assays, including receptor binding, internalization kinetics, and cellular retention studies; these experiments will be conducted independently or in close cooperation with team members
• Integration of feedback from biological testing to guide structural modifications and improve efficacy, specificity, and pharmacological profile
• Preparation of high-quality scientific manuscripts for peer-reviewed journals, as well as writing and contributing to competitive grant proposals and third-party funding applications
• Co-supervision of graduate students, interns, and early-career researchers; support includes training in synthetic chemistry, lab safety, and experimental planning, as well as mentoring on data interpretation, presentation, and scientific communication
• Regular presentation of research results at internal group meetings, institutional seminars, and national and international scientific conferences

Your Profile

• Applicants should have a master's degree and PhD in chemistry, biochemistry, medicinal chemistry, pharmaceutical sciences, or a closely related field. An academic or research focus on drug design, organic chemistry, inorganic chemistry, coordination/complexation chemistry, or radiopharmaceutical sciences is particularly advantageous.
• Prior experience in handling radionuclides, radiolabeling techniques, and radiopharmaceutical synthesis is highly desirable. However, motivated candidates without prior experience in this field but with a strong interest in radiochemistry are also encouraged to apply.
• Experience with cell culture, biological assays, and small animals is of significant advantage but not a prerequisite.
• Demonstrated ability to work effectively in interdisciplinary and multi-institutional teams is expected. A collaborative mindset, openness to scientific exchange, and a proactive attitude toward project development are essential in this dynamic research environment.
• Excellent written and verbal communication skills in English or German are required. Candidates should be capable of preparing scientific reports, manuscripts, and presentations, and engaging in professional discussions across disciplines.

We Offer

Are you interested?

 Then become part of the DKFZ and join us in contributing to a life without cancer!

 ​Duration: The position is initially limited to 2 years with the possibility of prolongation.

Application Deadline: 09.07.2025

Applications by e-mail cannot be accepted.

Please also note that we cannot return applications submitted by post.

 

We are convinced that an innovative research and working environment thrives on the diversity of its employees. Therefore, we welcome applications from talented people, regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical ability, religion and age. People with severe disabilities are given preference if they have the same aptitude.

Notice: We are subject to the regulations of the Infection Protection Act (IfSG). Therefore, all our employees must provide proof of immunity against measles.

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